ArticleCNS drugs2009
Complete suppression of craving in alcohol-dependent individuals: is it possible?
Article in CNS drugs, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 5 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recent preliminary, single-case report suggested that baclofen not only reduces but may completely suppress craving in alcohol-dependent individuals. The current article summarizes the neurobiological basis of drug craving, and the pharmacological targets that have been shown to be involved in modulating such craving. The potential usefulness of agents that suppress craving is discussed. However, beyond individual case reports, no evidence is available to indicate that targeting a single neurobiological pathway will be sufficient to completely suppress craving in unselected individuals. Nevertheless, subgroups that carry specific characteristics associated with single receptor dysfunction might benefit from a targeted treatment. Further research is needed to enable clinicians to detect these subgroups.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.