ArticleInorganic chemistry2009
Sensitivity of Ru(bpy)2dppz2+ luminescence to DNA defects.
Article in Inorganic chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 121 citations in OpenAlex.
- Metal complexes in medicine: structural scaffoldsChemical science · 2026Review
- Binding and stabilizating effect of RNA triplex poly(U)⋅poly(A)*poly(U) by enantiomers of ruthenium(II) polypyridyl complex [Ru(bpy)Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023Article
- Ruthenium-Locked Helical Chirality: A Barrier of Inversion and Formation of an Asymmetric Macrocycle.Inorganic chemistry · 2022Article
- Metallointercalators-DNA Tetrahedron Supramolecular Self-Assemblies with Increased Serum Stability.ACS nano · 2022Article
- Understanding the ancillary ligand effect on luminescent cyclometalated Ir(III) complex as a reporter for 2-acetylaminofluorene DNA(AAF-dG) adduct.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022Article
- AnChemical science · 2020Article
- Switch-on effect on conformation-specific arylamine-DNA adduct by cyclometalated Ir(III) complexes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020Article
- Flexibility and thermal dynamic stability increase of dsDNA induced by Ru(bpy)BMC chemistry · 2019Article
- Recent Developments in the Interactions of Classic Intercalated Ruthenium Compounds: [Ru(bpy)₂dppz]Molecules (Basel, Switzerland) · 2019Review
- A Ruthenium(II) Complex as a Luminescent Probe for DNA Mismatches and Abasic Sites.Inorganic chemistry · 2017Article
- Combining a Ru(II) "Building Block" and Rapid Screening Approach to Identify DNA Structure-Selective "Light Switch" Compounds.ACS combinatorial science · 2017Article
- Photochemical Tuning of Tris-Bidentate Acridine- and Phenazine-Based Ir(III) Complexes.Journal of fluorescence · 2016Article
- Ultrafast in cellulo photoinduced dynamics processes of the paradigm molecular light switch [Ru(bpy)2dppz](2.).Scientific reports · 2016Article
- [Ru(Me4phen)2dppz](2+), a Light Switch for DNA Mismatches.Journal of the American Chemical Society · 2016Article
- A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α.Scientific reports · 2016Article
- Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA.Nature communications · 2016Article
- Development of a luminescent G-quadruplex-selective iridium(III) complex for the label-free detection of adenosine.Scientific reports · 2016Article
- Ruthenium Complex "Light Switches" that are Selective for Different G-Quadruplex Structures.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Flexibility of short ds-DNA intercalated by a dipyridophenazine ligand.Frontiers in chemistry · 2015Article
- A ruthenium(II) complex supported by trithiacyclononane and aromatic diimine ligand as luminescent switch-on probe for biomolecule detection and protein staining.Scientific reports · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The luminescent characteristics of Ru(bpy)(2)dppz(2+) (dppz = dipyrido[3,2-a:2',3'-c]phenazine), a DNA light switch, were investigated in the presence of oligonucleotides containing single base mismatches or an abasic site. In water, the ruthenium luminescence is quenched, but, bound to well matched duplex DNA, the Ru complex luminesces. Here we show that with DNAs containing a defect, rac-, Delta-, and Lambda-Ru(bpy)(2)dppz(2+) exhibit significant luminescent enhancements above that with well matched DNA. In the presence of a single base mismatch, large luminescent enhancements are evident for the Delta-Ru isomer; the Lambda-isomer shows particularly high luminescence bound to an oligonucleotide containing an abasic site. Similar increases are not evident with two common DNA-binding organic fluorophores, ethidium bromide and TO-PRO-3. Titrations with hairpin oligonucleotides containing a variable mismatch site show correlation between the level of luminescent enhancement and the thermodynamic destabilization associated with the mismatch. This correlation is reminiscent of that found earlier for a bulky rhodium complex that binds mismatched DNA sites through metalloinsertion, where the complex binds the DNA from the minor groove side, ejecting the mismatched bases into the major groove. Differential quenching studies with minor and major groove quenchers and time-resolved emission studies support this metalloinsertion mode for the dppz complex at the defect site. Certainly these data underscore the utility of Ru(bpy)(2)dppz(2+) as a sensitive luminescent reporter of DNA and its defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.