ArticleScandinavian journal of infectious diseases2009
Risk factors for death after sepsis in patients immunosuppressed before the onset of sepsis.
Article in Scandinavian journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03617965 (Mortality Due to Septic Shock Associated With Thrombocytopenia in the Intensive Care Unit), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mortality Due to Septic Shock Associated With Thrombocytopenia in the Intensive Care Unit
Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Eravacycline use in immunocompromised patients: multicenter evaluation of timely versus late initiation on clinical outcomes.Microbiology spectrum · 2025Observational
- Further considerations on the clinical applicability of time to positivity as a prognostic tool for catheter-related pseudomonas aeruginosa bloodstream infections.Critical care (London, England) · 2025Article
- Clinical characteristics, risk factors and outcome of critically ill immunocompromised patients with bloodstream infections and sepsis.PloS one · 2025Article
- Lethal versus surviving sepsis phenotypes displayed a partly differential regional expression of neurotransmitters and inflammation and did not modify the blood-brain barrier permeability in female CLP mice.Intensive care medicine experimental · 2024Article
- Deficits in blood culture collection in the emergency department if sepsis is suspected: results of a retrospective cohort study.Infection · 2024Article
- Long-term immunosuppressive treatment is not associated with worse outcome in patients hospitalized in the intensive care unit for septic shock: the PACIFIC study.Critical care (London, England) · 2023Article
- Acute diverticulitis in immunocompromised patients: evidence from an international multicenter observational registry (Web-based International Register of Emergency Surgery and Trauma, Wires-T).Techniques in coloproctology · 2023Article
- Risk Factors for 30-Day Mortality in Patients with Bacteremic Pneumonia Caused byInternational journal of general medicine · 2023Article
- Body computed tomography in sepsis: predictors of CT findings and patient outcomes in a retrospective medical ICU cohort study.Emergency radiology · 2022Article
- Article
- Risk factor analysis and nomogram for predicting in-hospital mortality in ICU patients with sepsis and lung infection.BMC pulmonary medicine · 2022Article
- [Treatment of infections in the critically ill under immunosuppression : What must be considered?]Zeitschrift fur Rheumatologie · 2019Review
- Hospital Volume of Immunosuppressed Patients with Sepsis and Sepsis Mortality.Annals of the American Thoracic Society · 2018Article
- Distinct T-helper cell responses to Staphylococcus aureus bacteremia reflect immunologic comorbidities and correlate with mortality.Critical care (London, England) · 2018Article
- Evaluation of a novel 5-group classification system of sepsis by vasopressor use and initial serum lactate in the emergency department.Internal and emergency medicine · 2018Article
- Staphylococcus aureus bacteremia in immunosuppressed patients: a multicenter, retrospective cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Validation of a Method to Identify Immunocompromised Patients with Severe Sepsis in Administrative Databases.Annals of the American Thoracic Society · 2016Article
- Progression from severe sepsis in pregnancy to death: a UK population-based case-control analysis.BJOG : an international journal of obstetrics and gynaecology · 2015Article
- Risk factors for hospitalization due to community-acquired sepsis - a population-based case-control study.PloS one · 2015Article
- Immune dysfunction prior to Staphylococcus aureus bacteremia is a determinant of long-term mortality.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Few studies have focused on sepsis in patients with pre-existing immunosuppression. Since the numbers and the incidence of sepsis are increasing, sepsis in immunosuppressed patients will increase in importance. We studied the epidemiology of sepsis and risk factors for 28-d mortality in patients immunosuppressed prior to the onset of sepsis using data from the Academic Medical Center Consortium's (AMCC) prospective observational cohort study of sepsis. We compared characteristics of immunosuppressed (n =412) and immunocompetent (n =754) patients. Immunosuppressed patients were younger and more likely to have underlying liver or lung disease, and nosocomial infection or bloodstream infection of unknown source when presenting with sepsis. They were also more likely to die within 28 d compared to immunocompetent patients (adjusted relative risk 1.62, 95% CI 1.38 - 1.91). Septic shock, hypothermia, cancer and invasive fungal infections were associated with increased mortality in immunosuppressed patients. Black race and the presence of rigors were independent predictors of survival in immunosuppressed patients. We conclude that sepsis among patients immunosuppressed prior to the onset of sepsis was associated with higher mortality than in immunocompetent patients. As the numbers of immunosuppressed patients continue to grow, more studies on the epidemiology of sepsis in this group will become increasingly important.
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