ArticleImmunogenetics2009
Extremely high MHC class I variation in a population of a long-distance migrant, the Scarlet Rosefinch (Carpodacus erythrinus).
Article in Immunogenetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Long read genome unravels MHC I genomic architecture, evolution, and diversity loss iniScience · 2025Article
- The MHC (Major Histocmpatibility Complex) Exceptional Molecules of Birds and Their Relationship to Diseases.International journal of molecular sciences · 2025Review
- Distinct evolutionary trajectories of MHC class I and class II genes in Old World finches and buntings.Heredity · 2021Article
- The strength of selection is consistent across both domains of the MHC class I peptide-binding groove in birds.BMC ecology and evolution · 2021Article
- Molecular Characterization of MHC Class I Genes in Four Species of theBioMed research international · 2021Article
- Lack of evidence for selection favouring MHC haplotypes that combine high functional diversity.Heredity · 2018Article
- Extreme MHC class I diversity in the sedge warbler (Acrocephalus schoenobaenus); selection patterns and allelic divergence suggest that different genes have different functions.BMC evolutionary biology · 2017Article
- MHC class II β exon 2 variation in pardalotes (Pardalotidae) is shaped by selection, recombination and gene conversion.Immunogenetics · 2017Article
- New data from basal Australian songbird lineages show that complex structure of MHC class II β genes has early evolutionary origins within passerines.BMC evolutionary biology · 2016Article
- Balancing selection and recombination as evolutionary forces caused population genetic variations in golden pheasant MHC class I genes.BMC evolutionary biology · 2016Article
- High major histocompatibility complex class I polymorphism despite bottlenecks in wild and domesticated populations of the zebra finch (Taeniopygia guttata).BMC evolutionary biology · 2015Article
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- Immunomics of the koala (Phascolarctos cinereus).Immunogenetics · 2015Article
- Comparative genome analyses reveal distinct structure in the saltwater crocodile MHC.PloS one · 2014Article
- Characteristics of MHC class I genes in house sparrows Passer domesticus as revealed by long cDNA transcripts and amplicon sequencing.Journal of molecular evolution · 2013Article
- In silico peptide-binding predictions of passerine MHC class I reveal similarities across distantly related species, suggesting convergence on the level of protein function.Immunogenetics · 2013Article
- Characterization of MHC class I in a long-distance migrant shorebird suggests multiple transcribed genes and intergenic recombination.Immunogenetics · 2013Article
- Greater prairie chickens have a compact MHC-B with a single class IA locus.Immunogenetics · 2013Article
- MHC class IIB exon 2 polymorphism in the Grey partridge (Perdix perdix) is shaped by selection, recombination and gene conversion.PloS one · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the number of studies focusing on the major histocompatibility complex (MHC) in non-model vertebrates is increasing, results are often contradictory, and the structure of MHC is still poorly understood in wild species. Here, we describe the structure and diversity of exon 3 of MHC class I in a passerine bird, the Scarlet Rosefinch (Carpodacus erythrinus). Using capillary electrophoresis single-strand conformation polymorphism, we identified 82 different MHC class I variants in one Rosefinch population nesting at one site in the Czech Republic. Thus far, this is the highest intra-populational MHC class I variation observed in birds. We have not found support for 'minimal essential' MHC in this species since individuals exhibited between three and nine different exon 3 sequences, indicating that there may be at least five amplified MHC class I genes. By cloning, we obtained and analysed 29 exon sequences and found that all of them could be translated into potentially functional proteins. We also show that strong positive selection appears to be acting mainly, but not only, on previously described antigen-binding sites in MHC class I genes. Furthermore, our results indicate that recombination has played an important role in generating genetic diversity of these genes in the Scarlet Rosefinch; we discuss the significance of this extremely high genetic diversity in light of the life history traits of this species, such as long-distance migration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.