ReviewCell biochemistry and biophysics2009
Mechanical design of translocating motor proteins.
Review in Cell biochemistry and biophysics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed.
- DsbA is a redox-switchable mechanical chaperone.Chemical science · 2021Article
- Escapement mechanisms: Efficient free energy transduction by reciprocally-coupled gating.Proteins · 2020Article
- Force-Dependent Binding Constants.Biochemistry · 2019Review
- Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Elastic coupling power stroke mechanism of the FProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines.Biophysical reviews · 2015Article
- Modeling stochastic kinetics of molecular machines at multiple levels: from molecules to modules.Biophysical journal · 2013Review
- Modular aspects of kinesin force generation machinery.Biophysical journal · 2013Article
- Nucleotide-dependent control of internal strains in ring-shaped AAA+ motors.Cellular and molecular bioengineering · 2013Article
- Tagetitoxin inhibits RNA polymerase through trapping of the trigger loop.The Journal of biological chemistry · 2011Article
- Hysteresis-based mechanism for the directed motility of the Ncd motor.Biophysical journal · 2011Article
- The N-end rule pathway and regulation by proteolysis.Protein science : a publication of the Protein Society · 2011Review
- Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine.Cell · 2011Article
- Proteomic analysis of the slit diaphragm complex: CLIC5 is a protein critical for podocyte morphology and function.Kidney international · 2010Article
- Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function.Molecular & cellular biomechanics : MCB · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Translocating motors generate force and move along a biofilament track to achieve diverse functions including gene transcription, translation, intracellular cargo transport, protein degradation, and muscle contraction. Advances in single molecule manipulation experiments, structural biology, and computational analysis are making it possible to consider common mechanical design principles of these diverse families of motors. Here, we propose a mechanical parts list that include track, energy conversion machinery, and moving parts. Energy is supplied not just by burning of a fuel molecule, but there are other sources or sinks of free energy, by binding and release of a fuel or products, or similarly between the motor and the track. Dynamic conformational changes of the motor domain can be regarded as controlling the flow of free energy to and from the surrounding heat reservoir. Multiple motor domains are organized in distinct ways to achieve motility under imposed physical constraints. Transcending amino acid sequence and structure, physically and functionally similar mechanical parts may have evolved as nature's design strategy for these molecular engines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.