ArticleGlycobiology2009
Size-dependent regulation of Snail2 by hyaluronan: its role in cellular invasion.
Article in Glycobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Innovations in peritoneal dialysis fluid: biocompatible formulations and expanded therapeutic applications.Renal failure · 2025Review
- Differing Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy Resistance.Cancers · 2018Review
- Molecular machineries of pH dysregulation in tumor microenvironment: potential targets for cancer therapy.BioImpacts : BI · 2017Review
- Article
- Effects of corticosteroids and their combinations with hyaluronanon on the biochemical properties of porcine cartilage explants.BMC veterinary research · 2015Article
- Hyaluronan fragments as mediators of inflammation in allergic pulmonary disease.Immunobiology · 2015Review
- Type III TGFβ receptor and Src direct hyaluronan-mediated invasive cell motility.Cellular signalling · 2015Article
- ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis.Genes & development · 2015Article
- Hyaluronan - a functional and structural sweet spot in the tissue microenvironment.Frontiers in immunology · 2015Review
- Cardiac epithelial-mesenchymal transition is blocked by monomethylarsonous acid (III).Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Hyaluronan: a simple polysaccharide with diverse biological functions.Acta biomaterialia · 2014Review
- Emerging roles for hyaluronidase in cancer metastasis and therapy.Advances in cancer research · 2014Review
- Extracellular matrix macromolecules: potential tools and targets in cancer gene therapy.Molecular and cellular therapies · 2014Review
- BMP-2 induces versican and hyaluronan that contribute to post-EMT AV cushion cell migration.PloS one · 2013Article
- Hyaluronic acid promotes angiogenesis by inducing RHAMM-TGFβ receptor interaction via CD44-PKCδ.Molecules and cells · 2012Article
- Pathophysiology of the peritoneal membrane during peritoneal dialysis: the role of hyaluronan.Journal of biomedicine & biotechnology · 2011Review
- Hyaluronan as an immune regulator in human diseases.Physiological reviews · 2011Review
- TGFβ2-mediated production of hyaluronan is important for the induction of epicardial cell differentiation and invasion.Experimental cell research · 2010Article
- Involvement of the MEKK1 signaling pathway in the regulation of epicardial cell behavior by hyaluronan.Cellular signalling · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hyaluronan (HA) induces changes in cellular behavior that are crucial during both embryonic development and cancer progression. However, the biological effects of varying sizes of HA and the signal transduction mechanisms that these polymers may activate remain unclear. In this study, we demonstrate that pulse stimulation of mouse embryonic fibroblasts with high-molecular-weight (HMW) HA, but not HA of lower molecular sizes, leads to increases in Snail2 protein which are dependent on NFkappaB activity. Involvement of CD44, the main HA receptor, in these responses was determined by use of a CD44 blocking antibody and CD44 siRNA. Both the blockade and silencing of CD44 significantly abrogate the increases in nuclear factor kappaB (NFkappaB) activity and Snail2 protein following HMW-HA stimulation. Furthermore, we show that HMW-HA induces cellular invasion and that inhibition of CD44, Snail2, or NFkappaB significantly decreases this response. These studies elucidate a novel HA/Snail2 functional connection through CD44 and NFkappaB that is important for the induction of cellular invasion and is dependent on HA size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.