Evidence map›Paper›PMID 19451289›Full record

ArticleAntimicrobial agents and chemotherapy2009

Efficacy of liposomal amphotericin B combined with gamma interferon or granulocyte-macrophage colony-stimulating factor for treatment of systemic zygomycosis in mice.

M Mar Rodríguez, Enrique Calvo, Marçal Mariné, F Javier Pastor, Joan Fernandez-Ballart, Josep Guarro

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. The mucormycete-host interface.Current opinion in microbiology · 2017
    Review
  3. Article
  4. Combination therapy for mucormycosis: why, what, and how?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

M Mar RodríguezUnitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain.
Enrique Calvo
Marçal Mariné
F Javier Pastor
Joan Fernandez-Ballart
Josep Guarro
Universidad Rovira i Virgili · ESInstitut d'Investigació Sanitària Pere Virgili · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Granulocyte-macrophage colony-stimulating factor enhanced the efficacy of liposomal amphotericin B (LAMB) in a murine model of disseminated infection by Rhizopus oryzae, significantly prolonging survival and reducing tissue burden. The use of gamma interferon (IFN-gamma) alone was ineffective, and IFN-gamma combined with LAMB did not improve the results obtained with LAMB alone.

Indexed as

Amphotericin BAnimalsAntifungal AgentsGranulocyte-Macrophage Colony-Stimulating FactorInterferon-gammaMaleMiceRhizopusZygomycosisAmphotericin BAntifungal AgentsGranulocyte-Macrophage Colony-Stimulating FactorInterferon-gammaliposomal amphotericin B

Identifiers

PMID19451289
PMCPMC2715637
OpenAlexW2107892446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.