ArticleThe Journal of physiology2009
Intercostal muscle blood flow limitation in athletes during maximal exercise.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Muscle Oximetry in Sports Science: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2018Pooled it
- Effects of combining forearm postexercise muscle ischemia with inspiratory loading on cardiovascular and muscle oxygenation responses.European journal of applied physiology · 2026Trial
- Regional tissue oxygenation during high-intensity exercise following voluntary isocapnic hyperpnea versus inspiratory threshold loading in endurance-trained individuals: a randomized controlled trial.Scientific reports · 2026Trial
- Pressure-dependent coupling between arterial pressure and intercostal muscle blood-flow index during acute hypotension in humans.Experimental physiology · 2026Article
- Muscle and cerebral oxygenation during exercise in fibromyalgia: a near-infrared spectroscopy study.European journal of applied physiology · 2026Article
- Sex differences in the prefrontal cortex and muscle oxygenation during exercise until exhaustion in endurance-trained individuals.Experimental physiology · 2025Article
- Increases in skin perfusion and blood oxygen in the non-exercising human limbs during exercise in the heat: Implications for control of circulation.Experimental physiology · 2025Article
- The heart, a secondary organ in the control of blood circulation.Experimental physiology · 2025Review
- Monitoring Changes in Oxygen Muscle during Exercise with High-Flow Nasal Cannula Using Wearable NIRS Biosensors.Biosensors · 2023Article
- Assessment of Intercostal Muscle Near-Infrared Spectroscopy for Estimating Respiratory Compensation Point in Trained Endurance Athletes.Sports (Basel, Switzerland) · 2023Article
- Article
- Review
- Influence of a Six-Week Swimming Training with Added Respiratory Dead Space on Respiratory Muscle Strength and Pulmonary Function in Recreational Swimmers.International journal of environmental research and public health · 2020Article
- New Insights into Mechanical, Metabolic and Muscle Oxygenation Signals During and After High-Intensity Tethered Running.Scientific reports · 2020Article
- Competition for blood flow distribution between respiratory and locomotor muscles: implications for muscle fatigue.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Effect of chronic heart failure in older rats on respiratory muscle and hindlimb blood flow during submaximal exercise.Respiratory physiology & neurobiology · 2017Article
- Whole body hyperthermia, but not skin hyperthermia, accelerates brain and locomotor limb circulatory strain and impairs exercise capacity in humans.Physiological reports · 2017Article
- An integrated view on the oxygenation responses to incremental exercise at the brain, the locomotor and respiratory muscles.European journal of applied physiology · 2016Review
- Cardiovascular control during whole body exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
- The respiratory muscles during exercise.Breathe (Sheffield, England) · 2016Article
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
We investigated whether, during maximal exercise, intercostal muscle blood flow is as high as during resting hyperpnoea at the same work of breathing. We hypothesized that during exercise, intercostal muscle blood flow would be limited by competition from the locomotor muscles. Intercostal (probe over the 7th intercostal space) and vastus lateralis muscle perfusion were measured simultaneously in ten trained cyclists by near-infrared spectroscopy using indocyanine green dye. Measurements were made at several exercise intensities up to maximal (WRmax) and subsequently during resting isocapnic hyperpnoea at minute ventilation levels up to those at WRmax. During resting hyperpnoea, intercostal muscle blood flow increased linearly with the work of breathing (R2 = 0.94) to 73.0 +/- 8.8 ml min-1 (100 g)-1 at the ventilation seen at WRmax (work of breathing approximately 550-600 J min-1), but during exercise it peaked at 80% WRmax (53.4 +/- 10.3 ml min-1 (100 g)-1), significantly falling to 24.7 +/- 5.3 ml min-1 (100 g)-1 at WRmax. At maximal ventilation intercostal muscle vascular conductance was significantly lower during exercise (0.22 +/- 0.05 ml min-1 (100 g)-1 mmHg-1) compared to isocapnic hyperpnoea (0.77 +/- 0.13 ml min-1 (100 g)-1 mmHg-1). During exercise, both cardiac output and vastus lateralis muscle blood flow also plateaued at about 80% WRmax (the latter at 95.4 +/- 11.8 ml min-1 (100 g)-1). In conclusion, during exercise above 80% WRmax in trained subjects, intercostal muscle blood flow and vascular conductance are less than during resting hyperpnoea at the same minute ventilation. This suggests that the circulatory system is unable to meet the demands of both locomotor and intercostal muscles during heavy exercise, requiring greater O2 extraction and likely contributing to respiratory muscle fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.