ArticleParkinsonism & related disorders2009
Evaluation of gastric emptying in familial and sporadic Parkinson disease.
Article in Parkinsonism & related disorders, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- Gastroparesis in Parkinson's disease: Diagnostic and clinical implications for optimizing pharmacological treatment.Journal of Parkinson's disease · 2026Review
- Gastric-filling ultrasonography to evaluate gastric motility in patients with Parkinson's disease.Frontiers in neurology · 2024Article
- Gastric Emptying Is Not Delayed and Does Not Correlate With Attenuated Postprandial Blood Flow Increase in Medicated Patients With Early Parkinson's Disease.Frontiers in neurology · 2022Article
- Gastroretentive Technologies in Tandem with Controlled-Release Strategies: A Potent Answer to Oral Drug Bioavailability and Patient Compliance Implications.Pharmaceutics · 2021Review
- "New methods of assessing autonomic disorders in Parkinson disease patients: skin-galvanic reaction".Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Probiotics for Parkinson's Disease.International journal of molecular sciences · 2019Review
- Current State and Future Perspectives on Gastroretentive Drug Delivery Systems.Pharmaceutics · 2019Review
- Microbial treatment: the potential application for Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Review
- Imaging the Autonomic Nervous System in Parkinson's Disease.Current neurology and neuroscience reports · 2018Review
- Imaging Parkinson's disease below the neck.NPJ Parkinson's disease · 2017Article
- Imaging Systemic Dysfunction in Parkinson's Disease.Current neurology and neuroscience reports · 2016Review
- Small intestine dysfunction in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Neurogenic bowel dysfunction in patients with spinal cord injury, myelomeningocele, multiple sclerosis and Parkinson's disease.World journal of gastroenterology · 2011Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo assess for the presence of gastric dysmotility in familial and sporadic Parkinson disease (PD).
methods10 subjects with familial Parkinson disease (fPD), 35 subjects with sporadic Parkinson disease (sPD), and 15 controls, all from academic tertiary care movement disorders centers, were studied. fPD was defined as the presence of at least 2 affected individuals within 2-3 consecutive generations in a family. Molecular genetic analysis has not revealed, thus far, any known genomic abnormality in these families. Gastric emptying was assessed by dynamic abdominal scintigraphy over 92 min following ingestion of a solid meal containing 99mTc-labeled colloid of 40 MBq activity. The main outcome measures were gastric emptying half-time and radiotracer activity over the gastric area at 46 and at 92 min.
resultsGastric emptying time was delayed in 60% of subjects with PD. In comparison to mean t(1/2) of 38 +/- 7 min in controls, mean t(1/2) was 58 +/- 25 min in fPD (p = 0.02) and 46 +/- 25 min in sPD (p = 0.10). Both fPD and sPD groups included subjects with delayed gastric emptying at an early stage of disease.
conclusionsPatients with fPD showed significantly delayed gastric emptying in comparison to normal age-matched individuals. Further studies of gastrointestinal dysfunction in PD, particularly fPD, are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.