ReviewNeuroscience2009
Challenges in phenotype definition in the whole-genome era: multivariate models of memory and intelligence.
Review in Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Beauty and Wellness in the Semantic Memory of the Beholder.Frontiers in psychology · 2021Article
- Verbal memory dysfunction is associated with alterations in brain transcriptome in dominant temporal lobe epilepsy.Epilepsia · 2020Article
- Neurocognitive and Psychiatric Markers for Addiction: Common vs. Specific Endophenotypes for Heroin and Amphetamine Dependence.Current topics in medicinal chemistry · 2020Article
- Heritability of tic disorders: a twin-family study.Psychological medicine · 2017Article
- The digital revolution in phenotyping.Briefings in bioinformatics · 2016Article
- Neurocognitive functioning and genetic variation in patients with primary brain tumours.The Lancet. Oncology · 2016Review
- Genetics of cognition in epilepsy.Epilepsy & behavior : E&B · 2014Review
- Genetic complexity of episodic memory: a twin approach to studies of aging.Psychology and aging · 2014Article
- From genes to behavior: placing cognitive models in the context of biological pathways.Frontiers in neuroscience · 2014Article
- High-throughput cognitive assessment using BrainTest.org: examining cognitive control in a family cohort.Brain and behavior · 2013Article
- Meta-analysis methods for genome-wide association studies and beyond.Nature reviews. Genetics · 2013Review
- Correction of phenotype misclassification based on high-discrimination genetic predictive risk models.Epidemiology (Cambridge, Mass.) · 2012Article
- Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors.Addictive behaviors · 2012Article
- The genetics of cognitive impairment in schizophrenia: a phenomic perspective.Trends in cognitive sciences · 2011Review
- Empirically derived subtypes of opioid use and related behaviors.Addiction (Abingdon, England) · 2011Article
- Impact of phenotype definition on genome-wide association signals: empirical evaluation in human immunodeficiency virus type 1 infection.American journal of epidemiology · 2011Article
- The search for biomarkers and endophenotypes in functional gastrointestinal disorders.Gastroenterology · 2011Article
- Schizophrenia, "Just the Facts" 6. Moving ahead with the schizophrenia concept: from the elephant to the mouse.Schizophrenia research · 2011Review
- Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium.Osteoarthritis and cartilage · 2011Article
- Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder.European child & adolescent psychiatry · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Refining phenotypes for the study of neuropsychiatric disorders is of paramount importance in neuroscience. Poor phenotype definition provides the greatest obstacle for making progress in disorders like schizophrenia, bipolar disorder, Attention Deficit/Hyperactivity Disorder (ADHD), and autism. Using freely available informatics tools developed by the Consortium for Neuropsychiatric Phenomics (CNP), we provide a framework for defining and refining latent constructs used in neuroscience research and then apply this strategy to review known genetic contributions to memory and intelligence in healthy individuals. This approach can help us begin to build multi-level phenotype models that express the interactions between constructs necessary to understand complex neuropsychiatric diseases. These results are available online through the http://www.phenowiki.org database. Further work needs to be done in order to provide consensus-building applications for the broadly defined constructs used in neuroscience research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.