ArticleBiophysical journal2009
A kinetic model of the inositol trisphosphate receptor based on single-channel data.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Stochastic model of IP3-induced Ca2+ spiking of HEK293 cells.PLoS computational biology · 2025Article
- Structural titration reveals CaNature communications · 2023Article
- Modeling IPBiophysical journal · 2023Article
- An integrate-and-fire approach to CaBiophysical journal · 2023Article
- Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity.PLoS computational biology · 2019Article
- Inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum: A single-channel point of view.Cell calcium · 2015Review
- Multiscale modelling of saliva secretion.Mathematical biosciences · 2014Article
- Modelling mechanism of calcium oscillations in pancreatic acinar cells.Journal of bioenergetics and biomembranes · 2014Article
- Calcium and IP3 dynamics in cardiac myocytes: experimental and computational perspectives and approaches.Frontiers in pharmacology · 2014Review
- A stochastic model of calcium puffs based on single-channel data.Biophysical journal · 2013Article
- Patch-clamp electrophysiology of intracellular Ca2+ channels.Cold Spring Harbor protocols · 2013Article
- Article
- A kinetic model for type I and II IP3R accounting for mode changes.Biophysical journal · 2012Article
- A data-driven model of a modal gated ion channel: the inositol 1,4,5-trisphosphate receptor in insect Sf9 cells.The Journal of general physiology · 2012Article
- A multi-scale approach to airway hyperresponsiveness: from molecule to organ.Frontiers in physiology · 2012Article
- A dynamic model of saliva secretion.Journal of theoretical biology · 2010Article
- Regulation of IP(3)R Channel Gating by Ca(2+) and Ca(2+) Binding Proteins.Current topics in membranes · 2010Article
- Inositol trisphosphate receptor and ion channel models based on single-channel data.Chaos (Woodbury, N.Y.) · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In many cell types, the inositol trisphosphate receptor is one of the important components controlling intracellular calcium dynamics, and an understanding of this receptor is necessary for an understanding of calcium oscillations and waves. Based on single-channel data from the type-I inositol trisphosphate receptor, and using a Markov chain Monte Carlo approach, we show that the most complex time-dependent model that can be unambiguously determined from steady-state data is one with three closed states and one open state, and we determine how the rate constants depend on calcium. Because the transitions between these states are complex functions of calcium concentration, each model state must correspond to a group of physical states. We fit two different topologies and find that both models predict that the main effect of [Ca(2+)] is to modulate the probability that the receptor is in a state that is able to open, rather than to modulate the transition rate to the open state.
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Registered trials
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