ArticleBiophysical journal2009
Stability and liquid-liquid phase separation in mixed saturated lipid bilayers.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- The Phase Behavior and Organization of Sphingomyelin/Cholesterol Membranes: A Deuterium NMR Study.Biophysical journal · 2018Article
- Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells.Nature biotechnology · 2018Article
- Super-swelled lyotropic single crystals.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Registered and antiregistered phase separation of mixed amphiphilic bilayers.Biophysical journal · 2015Article
- Spontaneous formation of heterogeneous patches on polymer-lipid core-shell particle surfaces during self-assembly.Small (Weinheim an der Bergstrasse, Germany) · 2013Article
- The thermodynamics of simple biomembrane mimetic systems.Journal of pharmacy & bioallied sciences · 2011Article
- AFM investigations of phase separation in supported membranes of binary mixtures of POPC and an eicosanyl-based bisphosphocholine bolalipid.Langmuir : the ACS journal of surfaces and colloids · 2010Article
- Phase separation in biological membranes: integration of theory and experiment.Annual review of biophysics · 2010Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The phase stability of a fluid lipid bilayer composed of a mixture of DC(18)PC, (DSPC), and a shorter DCn(s) PC, with n(s) from 8 to 17, has been studied using a self-consistent field theory that explicitly includes molecular details and configurational properties of the lipid molecules. Phase separation between two liquid phases was found when there was a sufficient mismatch between the hydrophobic thicknesses of the two bilayers composed entirely of one component or the other. This occurs when n(s) <or = 12 and there is a sufficient concentration of the shorter lipid. The mixture separates into a thin bilayer depleted of DSPC and a thick bilayer enriched in DSPC. Even when there is no phase separation, as in the cases when there is either insufficient concentration of a sufficiently short lipid or any concentration of a lipid with n(s) > 12, we observe that the effect of the shorter lipid is to increase the susceptibility of the system to fluctuations in the concentration. This is of interest, given that a common motif for the anchoring of proteins to the plasma membrane is via a myristoyl chain, that is, one with 14 carbons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.