ArticleBiophysical journal2009
Adaptive-control model for neutrophil orientation in the direction of chemical gradients.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Impact of KRAS mutation on the tumor microenvironment in colorectal cancer.International journal of biological sciences · 2024Review
- The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer.Frontiers in immunology · 2021Review
- Convergent and Divergent Migratory Patterns of Human Neutrophils inside Microfluidic Mazes.Scientific reports · 2018Article
- Modeling neutrophil migration in dynamic chemoattractant gradients: assessing the role of exosomes during signal relay.Molecular biology of the cell · 2017Article
- Rapid Generation and Detection of Biomimetic Oxygen Concentration Gradients In Vitro.Scientific reports · 2017Article
- A dual-docking microfluidic cell migration assay (DIntegrative biology : quantitative biosciences from nano to macro · 2017Article
- A neutrophil treadmill to decouple spatial and temporal signals during chemotaxis.Lab on a chip · 2015Article
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- Microdevice integrating innate and adaptive immune responses associated with antigen presentation by dendritic cells.RSC advances · 2013Article
- Identifying network motifs that buffer front-to-back signaling in polarized neutrophils.Cell reports · 2013Article
- Tumor cell migration in complex microenvironments.Cellular and molecular life sciences : CMLS · 2013Review
- Phenotyping patient-derived cells for translational studies in cardiovascular disease.Circulation · 2011Review
- A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.PLoS computational biology · 2011Review
- Directional decisions during neutrophil chemotaxis inside bifurcating channels.Integrative biology : quantitative biosciences from nano to macro · 2010Article
- Microfluidic technologies for temporal perturbations of chemotaxis.Annual review of biomedical engineering · 2010Review
- A new method for studying gradient-induced neutrophil desensitization based on an open microfluidic chamber.Lab on a chip · 2010Article
- Spontaneous migration of cancer cells under conditions of mechanical confinement.Integrative biology : quantitative biosciences from nano to macro · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Neutrophils have a remarkable ability to detect the direction of chemoattractant gradients and move directionally in response to bacterial infections and tissue injuries. For their role in health and disease, neutrophils have been extensively studied, and many of the molecules involved in the signaling mechanisms of gradient detection and chemotaxis have been identified. However, the cellular-scale mechanisms of gradient sensing and directional neutrophil migration have been more elusive, and existent models provide only limited insight into these processes. Here, we propose a what we believe is a novel adaptive-control model for the initiation of cell polarization in response to gradients. In this model, the neutrophils first sample the environment by extending protrusions in random directions and subsequently adapt their sensitivity depending on localized, temporal changes in stimulation levels. Our results suggest that microtubules may play a critical role in integrating all the sensing events from the cellular periphery through their redistribution inside the neutrophils, and may also be involved in modulating local signaling. An unexpected finding was that model neutrophils exhibit significant randomness in timing and directionality of activation, comparable to our experimental observations in microfluidic devices. Moreover, their responses are robust against alterations of the rate and amplitude of the signaling reactions, and for a broad range in chemoattractant concentrations and spatial gradients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.