ArticleBiophysical journal2009
K+/Na+ selectivity in toy cation binding site models is determined by the 'host'.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The Molecular Mechanism of Ion Selectivity in Nanopores.Molecules (Basel, Switzerland) · 2024Article
- An entropic mechanism of generating selective ion binding in macromolecules.PLoS computational biology · 2013Article
- Probing the thermodynamics of competitive ion binding using minimum energy structures.The journal of physical chemistry. B · 2011Article
- Perspectives on: ion selectivity: design principles for K+ selectivity in membrane transport.The Journal of general physiology · 2011Article
- Mapping the importance of four factors in creating monovalent ion selectivity in biological molecules.Biophysical journal · 2011Article
- Multibody effects in ion binding and selectivity.Biophysical journal · 2010Article
- Selective complexation of K+ and Na+ in simple polarizable ion-ligating systems.Journal of the American Chemical Society · 2010Article
- Exploring the ion selectivity properties of a large number of simplified binding site models.Biophysical journal · 2010Article
- Ion selectivity from local configurations of ligands in solutions and ion channels.Chemical physics letters · 2010Article
- Protein structure and ionic selectivity in calcium channels: selectivity filter size, not shape, matters.Biochimica et biophysica acta · 2009Article
- Statistical determinants of selective ionic complexation: ions in solvent, transport proteins, and other "hosts".Biophysical journal · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The macroscopic ion-selective behavior of K(+) channels is mediated by a multitude of physiological factors. However, considering the carbonyl-lined binding site of a conductive K(+) channel as a canonical eightfold coordinated construct can be useful in understanding the principles that correlate the channel's structure with its function. We probe the effects of structure and chemical composition on the K(+)/Na(+) selectivity provided by a variety of simplified droplet-like ion binding site models. We find that when carbonyl- and water-based models capture the qualitative structural features of the K(+) channel binding site, a selective preference for K(+) emerges. Thus our findings suggest that the preference for K(+) over Na(+) exhibited by such models is principally built-in, and is not due to a unique K(+)-selective property of carbonyl functional groups. This suggestion is confirmed by a general thermodynamic assessment, which provides a basis for using simplified models to study the design principles underlying the molecular evolution of K(+) channels.
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