ArticleExperimental eye research2009
Altered F-actin distribution in retinal nerve fiber layer of a rat model of glaucoma.
Article in Experimental eye research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Longitudinal detection of retinal alterations by visible and near-infrared optical coherence tomography in a dexamethasone-induced ocular hypertension mouse model.Neurophotonics · 2019Article
- Temporal change of retinal nerve fiber layer reflectance speckle in normal and hypertensive retinas.Experimental eye research · 2019Article
- Cytoskeletal Alteration and Change of Retinal Nerve Fiber Layer Birefringence in Hypertensive Retina.Current eye research · 2017Article
- Reflectance Spectrum and Birefringence of the Retinal Nerve Fiber Layer With Hypertensive Damage of Axonal Cytoskeleton.Investigative ophthalmology & visual science · 2017Article
- A Period of Controlled Elevation of IOP (CEI) Produces the Specific Gene Expression Responses and Focal Injury Pattern of Experimental Rat Glaucoma.Investigative ophthalmology & visual science · 2016Article
- Expansions of the neurovascular scleral canal and contained optic nerve occur early in the hypertonic saline rat experimental glaucoma model.Experimental eye research · 2016Article
- Retinal nerve fiber layer reflectometry must consider directional reflectance.Biomedical optics express · 2016Article
- Article
- In vivo imaging methods to assess glaucomatous optic neuropathy.Experimental eye research · 2015Review
- Modeling glaucoma in rats by sclerosing aqueous outflow pathways to elevate intraocular pressure.Experimental eye research · 2015Review
- Anterior lamina cribrosa surface depth, age, and visual field sensitivity in the Portland Progression Project.Investigative ophthalmology & visual science · 2014Article
- Classification of axonal subtypes based on cytoskeletal components.Cell health and cytoskeleton · 2014Article
- Wavelength-dependent change of retinal nerve fiber layer reflectance in glaucomatous retinas.Investigative ophthalmology & visual science · 2012Article
- Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma.Investigative ophthalmology & visual science · 2012Article
- Dual-band spectral-domain optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer.Optics express · 2011Article
- Reflectance decreases before thickness changes in the retinal nerve fiber layer in glaucomatous retinas.Investigative ophthalmology & visual science · 2011Article
- Pathophysiology of human glaucomatous optic nerve damage: insights from rodent models of glaucoma.Experimental eye research · 2011Review
- Distortion of axonal cytoskeleton: an early sign of glaucomatous damage.Investigative ophthalmology & visual science · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Glaucoma damages the retinal nerve fiber layer (RNFL). The purpose of this study was to investigate the distribution in RNFL of axonal F-actin, a cytoskeletal component, under the development of glaucoma. Intraocular hypertension was induced in a rat model by translimbal laser photocoagulation of the trabecular meshwork. The retinas of control and treated eyes were obtained after different exposures to elevated IOP. Nerve fiber bundles were identified by fluorescent phalloidin staining of F-actin. Nuclei of cell bodies were identified by DAPI fluorescent counterstain. F-actin distribution in whole-mounted retinas was examined by confocal microscopy. En face and cross-sectional images of RNFL were collected around the optic nerve head (ONH). F-actin in normal RNFL was intensely and uniformly stained. In glaucomatous retina, F-actin staining was not uniform within bundles and total loss of F-actin staining was found in severely damaged areas. Altered F-actin often occurred near the ONH in bundles that appeared normal more peripherally. Both alteration and total loss of F-actin were found most often in dorsal retina. In normal RNFL, F-actin is rich and approximately uniformly distributed within nerve fiber bundles. Elevated IOP changes F-actin distribution in RNFL. Topographic features of F-actin alteration suggest that F-actin near the ONH is more sensitive to glaucomatous damage. The alteration pattern also suggests an ONH location for the glaucomatous insult in this rat model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.