Trial reportCritical care (London, England)2009
Heliox reduces respiratory system resistance in respiratory syncytial virus induced respiratory failure.
Trial report in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Heliox inhalation therapy for bronchiolitis in infants.The Cochrane database of systematic reviews · 2015Pooled it
- Progress in the clinical application of heliox.Medical gas research · 2025Article
- Effectiveness of ultra-/very-high-frequency oscillations combined with helium-oxygen gas mixture in a rabbit model.Scientific reports · 2024Article
- Neonatal Applications of Heliox: A Practical Review.Frontiers in pediatrics · 2022Review
- Strategies and Advances in Combating COVID-19 in China.Engineering (Beijing, China) · 2020Review
- Estimating regions of air trapping from electrical impedance tomography data.Physiological measurement · 2018Article
- Short-term effects of neuromuscular blockade on global and regional lung mechanics, oxygenation and ventilation in pediatric acute hypoxemic respiratory failure.Annals of intensive care · 2016Article
- Mechanical ventilation with heliox in an animal model of acute respiratory distress syndrome.Intensive care medicine experimental · 2014Article
- The use of heliox in critical care.International journal of critical illness and injury science · 2014Article
- Heliox allows for lower minute volume ventilation in an animal model of ventilator-induced lung injury.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRespiratory syncytial virus (RSV) lower respiratory tract disease is characterised by narrowing of the airways resulting in increased airway resistance, air-trapping and respiratory acidosis. These problems might be overcome using helium-oxygen gas mixture. However, the effect of mechanical ventilation with heliox in these patients is unclear. The objective of this prospective cross-over study was to determine the effects of mechanical ventilation with heliox 60/40 versus conventional gas on respiratory system resistance, air-trapping and CO2 removal.
methodsMechanically ventilated, sedated and paralyzed infants with proven RSV were enrolled within 24 hours after paediatric intensive care unit (PICU)admission. At T = 0, respiratory system mechanics including respiratory system compliance and resistance, and peak expiratory flow rate were measured with the AVEA ventilator. The measurements were repeated at each interval (after 30 minutes of ventilation with heliox, after 30 minutes of ventilation with nitrox and again after 30 minutes of ventilation with heliox). Indices of gas exchange (ventilation and oxygenation index) were calculated at each interval. Air-trapping (defined by relative change in end-expiratory lung volume) was determined by electrical impedance tomography (EIT) at each interval.
resultsThirteen infants were enrolled. In nine, EIT measurements were performed. Mechanical ventilation with heliox significantly decreased respiratory system resistance. This was not accompanied by an improved CO2 elimination, decreased peak expiratory flow rate or decreased end-expiratory lung volume. Importantly, oxygenation remained unaltered throughout the experimental protocol.
conclusionsRespiratory system resistance is significantly decreased by mechanical ventilation with heliox (ISCRTN98152468).
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Registered trials
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