Trial reportHuman brain mapping2009
The effects of the glutamate antagonist memantine on brain activation to an auditory perception task.
Trial report in Human brain mapping, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Memantine effects on auditory discrimination and training in schizophrenia patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Correlation of non-auditory comorbidities and hearing loss in chronic subjective tinnitus patients: a retrospective database study.Frontiers in neurology · 2025Article
- Combined fMRI Region- and Network-Analysis Reveal New Insights of Top-Down Modulation of Bottom-Up Processes in Auditory Laterality.Frontiers in behavioral neuroscience · 2021Article
- [Doping for the brain].Zeitschrift fur Gerontologie und Geriatrie · 2018Review
- Enhancing Effects of NMDA-Receptor Blockade on Extinction Learning and Related Brain Activation Are Modulated by BMI.Frontiers in behavioral neuroscience · 2017Article
- Large-scale functional network overlap is a general property of brain functional organization: Reconciling inconsistent fMRI findings from general-linear-model-based analyses.Neuroscience and biobehavioral reviews · 2016Review
- Implications of cortical balanced excitation and inhibition, functional heterogeneity, and sparseness of neuronal activity in fMRI.Neuroscience and biobehavioral reviews · 2015Review
- Article
- Opposite modulation of brain functional networks implicated at low vs. high demand of attention and working memory.PloS one · 2014Article
- Task-related concurrent but opposite modulations of overlapping functional networks as revealed by spatial ICA.NeuroImage · 2013Article
- Spatial ICA reveals functional activity hidden from traditional fMRI GLM-based analyses.Frontiers in neuroscience · 2013Article
- Autism spectrum disorder, functional MRI and MR spectroscopy: possibilities and challenges.Microbial ecology in health and disease · 2012Article
- Drug therapy of post-stroke aphasia: a review of current evidence.Neuropsychology review · 2011Review
- Adults with attention-deficit/hyperactivity disorder - a brain magnetic resonance spectroscopy study.Frontiers in psychiatry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate is critically involved in the regulation of cognitive functions in humans. There is, however, sparse evidence regarding how blocking glutamate action at the receptor site during a cognitive task affects brain activation. In the current study, the effects of the glutamate antagonist memantine were examined with functional magnetic resonance imaging (fMRI). Thirty-one healthy adults were scanned twice in a counter-balanced design, either in a no-drug session or after administration of memantine for 21 days. The subjects performed a simple auditory perception task with consonant-vowel stimuli. Group-level spatial independent component analysis (ICA) was used to decompose the data and to extract task-related activations. The focus was on four task-related ICA components with frontotemporal localization. The results showed that glutamate-blockage resulted in a significant enhancement in one component, with no significant effect in the other three components. The enhanced effect of memantine was in the middle temporal gyrus, superior frontal gyrus, and middle frontal gyrus. It is suggested that the results reflect effects of glutamatergic processes primarily through non-N-methyl-D-aspartate (NMDA) receptor pathways. Moreover, the results demonstrate that memantine can be used as a probe which allows for studying the effect of excitatory neurotransmission on neuronal activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.