ArticleHuman brain mapping2009
Alterations in functional activation in euthymic bipolar disorder and schizophrenia during a working memory task.
Article in Human brain mapping, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Impact of THC and CBD in Schizophrenia: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Methodological recommendations for cognition trials in bipolar disorder by the International Society for Bipolar Disorders Targeting Cognition Task Force.Bipolar disorders · 2017Guideline
- Delayed match-to-sample in working memory: A BrainMap meta-analysis.Biological psychology · 2016Pooled it
- Triple network model of brain connectivity changes related to adverse mood effects in an oral contraceptive placebo-controlled trial.Translational psychiatry · 2023Trial
- Impaired visuospatial working memory but preserved attentional control in bipolar disorder.Psychological medicine · 2025Article
- Exploring the n-back task: insights, applications, and future directions.Frontiers in human neuroscience · 2025Review
- Neural Responses to a Working Memory Task in Acute Depressed and Remitted Phases in Bipolar Patients.Brain sciences · 2023Article
- Mechanisms underlying dorsolateral prefrontal cortex contributions to cognitive dysfunction in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Transdiagnostic comparison of visual working memory capacity in bipolar disorder and schizophrenia.International journal of bipolar disorders · 2021Article
- Are working memory and glutamate concentrations involved in early-life stress and severity of psychosis?Brain and behavior · 2020Article
- Brain function during stages of working memory in schizophrenia and psychotic bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Article
- Understanding marijuana's effects on functional connectivity of the default mode network in patients with schizophrenia and co-occurring cannabis use disorder: A pilot investigation.Schizophrenia research · 2018Article
- Levels of Cognitive Control: A Functional Magnetic Resonance Imaging-Based Test of an RDoC Domain Across Bipolar Disorder and Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder-a systematic review of the magnetic resonance neuroimaging literature.NPJ schizophrenia · 2017Article
- Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations.NeuroImage. Clinical · 2017Article
- Approaches to Capture Variance Differences in Rest fMRI Networks in the Spatial Geometric Features: Application to Schizophrenia.Frontiers in neuroscience · 2016Article
- High-order interactions observed in multi-task intrinsic networks are dominant indicators of aberrant brain function in schizophrenia.NeuroImage · 2014Article
- WORKING MEMORY IMPAIRMENT AS AN ENDOPHENOTYPIC MARKER OF A SCHIZOPHRENIA DIATHESIS.Schizophrenia research. Cognition · 2014Article
- Basal ganglia and thalamic morphology in schizophrenia and bipolar disorder.Psychiatry research · 2014Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Dysfunctions in prefrontal cortical networks are thought to underlie working memory (WM) impairments consistently observed in both subjects with bipolar disorder and schizophrenia. It remains unclear, however, whether patterns of WM-related hemodynamic responses are similar in bipolar and schizophrenia subjects compared to controls. We used fMRI to investigate differences in blood oxygen level dependent activation during a WM task in 21 patients with euthymic bipolar I, 20 patients with schizophrenia, and 38 healthy controls. Subjects were presented with four stimuli (abstract designs) followed by a fifth stimulus and required to recall whether the last stimulus was among the four presented previously. Task-related brain activity was compared within and across groups. All groups activated prefrontal cortex (PFC), primary and supplementary motor cortex, and visual cortex during the WM task. There were no significant differences in PFC activation between controls and euthymic bipolar subjects, but controls exhibited significantly increased activation (cluster-corrected P < 0.05) compared to patients with schizophrenia in prefrontal regions including dorsolateral prefrontal cortex (DLPFC). Although the bipolar group exhibited intermediate percent signal change in a functionally defined DLPFC region of interest with respect to the schizophrenia and control groups, effects remained significant only between patients with schizophrenia and controls. Schizophrenia and bipolar disorder may share some behavioral, diagnostic, and genetic features. Differences in the patterns of WM-related brain activity across groups, however, suggest some diagnostic specificity. Both patient groups showed some regional task-related hypoactivation compared to controls across the brain. Within DLPFC specifically, patients with schizophrenia exhibited more severe WM-related dysfunction than bipolar subjects.
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