ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Apical polarity protein PrkCi is necessary for maintenance of spinal cord precursors in zebrafish.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model.PLoS genetics · 2022Article
- aPKC in neuronal differentiation, maturation and function.Neuronal signaling · 2019Review
- CNS myelination requires cytoplasmic dynein function.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- miR-219 regulates neural precursor differentiation by direct inhibition of apical par polarity proteins.Developmental cell · 2013Article
- Transgenic line with gal4 insertion useful to study morphogenesis of craniofacial perichondrium, vascular endothelium-associated cells, floor plate, and dorsal midline radial glia during zebrafish development.Development, growth & differentiation · 2012Article
- Subnuclear development of the zebrafish habenular nuclei requires ER translocon function.Developmental biology · 2011Article
- swap70 promotes neural precursor cell cycle exit and oligodendrocyte formation.Molecular and cellular neurosciences · 2011Article
- Cell biological regulation of division fate in vertebrate neuroepithelial cells.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- The neuroepithelial basement membrane serves as a boundary and a substrate for neuron migration in the zebrafish hindbrain.Neural development · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
During development, neural precursors divide to produce new precursors and cells that differentiate as neurons and glia. In Drosophila, apicobasal polarity and orientation of the mitotic spindle play important roles in specifying the progeny of neural precursors for different fates. We examined orientation of zebrafish spinal cord precursors using time-lapse imaging and tested the function of protein kinase C, iota (PrkCi), a member of the Par complex of proteins necessary for apicobasal polarity in the nervous system. We found that nearly all precursors divide within the plane of the neuroepithelium of wild-type embryos even when they must produce cells that have different fates. In the absence of PrkCi function, neural precursor divisions become oblique during late embryogenesis and excess oligodendrocytes form concomitant with loss of dividing cells. We conclude that PrkCi function and planar divisions are necessary for asymmetric, self-renewing division of spinal cord precursors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.