ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Identification of genes expressed preferentially in the developing peripheral margin of the optic cup.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
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- Comparing the transcriptome of developing native and iPSC-derived mouse retinae by single cell RNA sequencing.Scientific reports · 2023Article
- Molecular networks of the FOXP2 transcription factor in the brain.EMBO reports · 2021Review
- Meis homeobox genes control progenitor competence in the retina.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Single-Cell RNA Sequencing of Retina:New Looks for Gene Marker and Old Diseases.Frontiers in molecular biosciences · 2021Review
- The transcription factorDisease models & mechanisms · 2020Article
- Localization ofThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- Single-Cell RNA Sequencing of hESC-Derived 3D Retinal Organoids Reveals Novel Genes Regulating RPC Commitment in Early Human Retinogenesis.Stem cell reports · 2019Article
- The peripheral eye: A neurogenic area with potential to treat retinal pathologies?Progress in retinal and eye research · 2019Review
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- Multimodal Regulation Orchestrates Normal and Complex Disease States in the Retina.Scientific reports · 2017Article
- The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells.Cell reports · 2016Article
- WNT/β-Catenin Signaling in Vertebrate Eye Development.Frontiers in cell and developmental biology · 2016Review
- Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma.Development (Cambridge, England) · 2015Article
- Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse.Development (Cambridge, England) · 2015Article
- Epithelial morphogenesis: the mouse eye as a model system.Current topics in developmental biology · 2015Review
- Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling.Neural development · 2014Article
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- Proliferation potential of Müller glia after retinal damage varies between mouse strains.PloS one · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Specification of the peripheral optic cup by Wnt signaling is critical for formation of the ciliary body/iris. Identification of marker genes for this region during development provides a starting point for functional analyses. During transcriptional profiling of single cells from the developing eye, two cells were identified that expressed genes not found in most other single cell profiles. In situ hybridizations demonstrated that many of these genes were expressed in the peripheral optic cup in both early mouse and chicken development, and in the ciliary body/iris at subsequent developmental stages. These analyses indicate that the two cells probably originated from the developing ciliary body/iris. Changes in expression of these genes were assayed in embryonic chicken retinas when canonical Wnt signaling was ectopically activated by CA-beta-catenin. Twelve ciliary body/iris genes were identified as upregulated following induction, suggesting they are excellent candidates for downstream effectors of Wnt signaling in the optic cup.
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Registered trials
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