Evidence map›Paper›PMID 19449082›Full record

Trial reportClinical orthopaedics and related research2009

One-step bone marrow-derived cell transplantation in talar osteochondral lesions.

Sandro Giannini, Roberto Buda, Francesca Vannini, Marco Cavallo, Brunella Grigolo

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical orthopaedics and related research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 4 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 4 syntheses or guidelines pooled it, 291 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Stem cells in articular cartilage regeneration.Journal of orthopaedic surgery and research · 2016
    Pooled it
  4. Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2013
    Pooled it
  5. The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015
    Trial
  6. Review
  7. Article
  8. Review
  9. Infiltration therapy in the context of cartilage surgery.Archives of orthopaedic and trauma surgery · 2024
    Review
  10. Review
  11. Top 50 Most-Cited Studies about Osteochondritis Dissecans.Arthroscopy, sports medicine, and rehabilitation · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Observational
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sandro GianniniVI Department of Orthopaedic and Traumatology, Istituto Ortopedico Rizzoli, University of Bologna, Via GC Pupilli 1, 40136 Bologna, Italy.
Roberto Buda
Francesca Vannini
Marco Cavallo
Brunella Grigolo
University of Bologna · ITIstituto Ortopedico Rizzoli · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThe ideal treatment of osteochondral lesions is debatable. Although autologous chondrocyte implantation provides pain relief, the need for two operations and high costs has prompted a search for alternatives. Bone marrow-derived cells may represent the future in osteochondral repair. Using a device to concentrate bone marrow-derived cells and collagen powder or hyaluronic acid membrane as scaffolds for cell support and platelet gel, a one-step arthroscopic technique was developed for cartilage repair. We performed an in vitro preclinical study to verify the capability of bone marrow-derived cells to differentiate into chondrogenic and osteogenic lineages and to be supported onto scaffolds. In a prospective clinical study, we investigated the ability of this technique to repair talar osteochondral lesions in 48 patients. Minimum followup was 24 months (mean, 29 months; range, 24-35 months). Clinical results were evaluated using the American Orthopaedic Foot and Ankle Society (AOFAS) score and the influence of scaffold type, lesion area, previous surgeries, and lesion depth was considered. MRI and histologic evaluation were performed. The AOFAS score improved from 64.4 +/- 14.5 to 91.4 +/- 7.7. Histologic evaluation showed regenerated tissue in various degrees of remodeling although none showed entirely hyaline cartilage. These data suggest the one-step technique is an alternative for cartilage repair, permitting improved functional scores and overcoming the drawbacks of previous techniques. LEVEL OF EVIDENCE: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

Indexed as

ArthroscopyBone Marrow TransplantationAdolescentAdultAnkle InjuriesBone RegenerationCell DifferentiationCells, CulturedCell SeparationChondrocytesChondrogenesisCollagenFemaleGelsHumansHyaluronic AcidCollagenGelsHyaluronic Acid

Identifiers

PMID19449082
PMCPMC2772930
OpenAlexW2097869914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.