ArticleJournal of molecular evolution2009
An unusual recent expansion of the C-terminal domain of RNA polymerase II in primate malaria parasites features a motif otherwise found only in mammalian polymerases.
Article in Journal of molecular evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Vive la Différence: Exploiting the Differences between Rodent and Human Malarias.Trends in parasitology · 2020Review
- Article
- Comparative 3D genome organization in apicomplexan parasites.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Repetitive sequences in malaria parasite proteins.FEMS microbiology reviews · 2017Review
- The serine/threonine phosphatases of apicomplexan parasites.Molecular microbiology · 2017Review
- Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum.Nucleic acids research · 2017Article
- Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates Novel Localization Sequences That Target the Periphery of the Host Erythrocyte.The Journal of biological chemistry · 2016Article
- DNA Instability Maintains the Repeat Length of the Yeast RNA Polymerase II C-terminal Domain.The Journal of biological chemistry · 2016Article
- Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells.eLife · 2015Article
- The Emerging Role for RNA Polymerase II in Regulating Virulence Gene Expression in Malaria Parasites.PLoS pathogens · 2015Review
- Evolution of lysine acetylation in the RNA polymerase II C-terminal domain.BMC evolutionary biology · 2015Article
- Genome-wide analysis in Plasmodium falciparum reveals early and late phases of RNA polymerase II occupancy during the infectious cycle.BMC genomics · 2014Article
- Homopolymer tract organization in the human malarial parasite Plasmodium falciparum and related Apicomplexan parasites.BMC genomics · 2014Article
- Evolutionary diversity and taxon-specific modifications of the RNA polymerase II C-terminal domain.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Recruitment of PfSET2 by RNA polymerase II to variant antigen encoding loci contributes to antigenic variation in P. falciparum.PLoS pathogens · 2014Article
- Horizontal gene transfer of epigenetic machinery and evolution of parasitism in the malaria parasite Plasmodium falciparum and other apicomplexans.BMC evolutionary biology · 2013Article
- Describing sequence-ensemble relationships for intrinsically disordered proteins.The Biochemical journal · 2013Review
- Transcription sites are developmentally regulated during the asexual cycle of Plasmodium falciparum.PloS one · 2013Article
- Erasing the epigenetic memory and beginning to switch--the onset of antigenic switching of var genes in Plasmodium falciparum.PloS one · 2012Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The tail of the enzyme RNA polymerase II is responsible for integrating the diverse events of gene expression in eukaryotes and is indispensable for life in yeast, fruit flies, and mice. The tail features a C-terminal domain (CTD), which is comprised of tandemly repeated Y(1)-S(2)-P(3)-T(4)-S(5)-P(6)-S(7) amino acid heptads that are highly conserved across evolutionary lineages, with all mammalian polymerases featuring 52 identical heptad repeats. However, the composition and function of protozoan CTDs remain less well understood. We find that malaria parasites (genus Plasmodium) display an unprecedented plasticity within the length and composition of their CTDs. The CTD in malaria parasites which infect human and nonhuman primates has expanded compared to closely related species that infect rodents or birds. In addition, this variability extends to different isolates within a single species, such as isolates of the human malaria parasite, Plasmodium falciparum. Our results indicate that expanded CTD heptads in malaria parasites correlates with parasitism of primates and provide the first demonstration of polymorphism of the RNA polymerase II CTD within a single species. The expanded set of CTD heptads feature lysine in the seventh position (Y(1)-S(2)-P(3)-T(4)-S(5)-P(6)-K(7)), a sequence only seen otherwise in the distal portion of mammalian polymerases. These observations raise new questions for the radiation of malaria parasites into diverse hosts and for the molecular evolution of RNA polymerase II.
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