ArticleJournal of psychiatry & neuroscience : JPN2009
Positive association of the pericentrin (PCNT) gene with major depressive disorder in the Japanese population.
Article in Journal of psychiatry & neuroscience : JPN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Family-Based Analysis Combined with Case-Controls Study Implicate Roles of PCNT in Tourette Syndrome.Neuropsychiatric disease and treatment · 2020Article
- Autism spectrum disorder, anxiety and severe depression in a male patient with deletion and duplication in the 21q22.3 region: A case report.Biomedical reports · 2019Article
- Article
- A Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder.International journal of molecular sciences · 2017Article
- Genetic distribution and association analysis of DRD2 gene polymorphisms with major depressive disorder in the Chinese Han population.International journal of clinical and experimental pathology · 2013Article
- A-kinase anchoring proteins as potential drug targets.British journal of pharmacology · 2012Review
- DISC1-binding proteins in neural development, signalling and schizophrenia.Neuropharmacology · 2012Review
- PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis.The Journal of cell biology · 2011Article
- Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population.PloS one · 2010Article
- Association study between the pericentrin (PCNT) gene and schizophrenia.Neuromolecular medicine · 2010Article
- Pericentrin in cellular function and disease.The Journal of cell biology · 2010Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPericentrin (PCNT) interacts with disruption-in-schizophrenia 1 (DISC1), a known genetic risk factor for schizophrenia, bipolar disorder and major depressive disorder (MDD). We sought to determine whether the PCNT gene is implicated in MDD.
methodsWe performed case-control association analyses in the Japanese population. We analyzed 9 single nucleotide polymorphisms (SNPs) in 173 patients with MDD and 348 healthy controls.
resultsWe found a significant allelic association between 3 SNPs (rs3788265, rs2073376 and rs2073380) of the PCNT gene and MDD (p = 0.006, 0.005 and 0.021, respectively). After correction for multiple testing, 2 SNPs (rs3788265 and rs2073376) retained significant allelic associations with MDD. In addition, we found a significant association between the 2 marker haplotypes (r3788265 and rs2073376) and MDD (permutation p = 0.011). LIMITATIONS: Our sample was small and comprised only Japanese participants. In addition, owing to the late onset of MDD, it is possible that the disorder will develop in at least some participants in our control group. Finally, we did not show how SNPs of the PCNT gene alter its function.
conclusionOur results suggest that genetic variations in the PCNT gene may play a significant role in the etiology of MDD in the Japanese population.
Indexed as
Identifiers
19448849PMC2674972W80311255What OpenQuestion holds
Registered trials
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