ArticleJournal of psychiatry & neuroscience : JPN2009
Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls.
Article in Journal of psychiatry & neuroscience : JPN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 43 citations in OpenAlex.
- Neurobiological substrates of major psychiatry disorders: transdiagnostic associations between white matter abnormalities, neuregulin 1 and clinical manifestation.Journal of psychiatry & neuroscience : JPN · 2021Article
- Shaping the Trans-Scale Properties of SchizophreniaFrontiers in human neuroscience · 2021Review
- Neuregulins in Neurodegenerative Diseases.Frontiers in aging neuroscience · 2021Article
- BACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia.Frontiers in molecular neuroscience · 2017Review
- Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia.Neuroscience bulletin · 2015Review
- Diffusion tensor imaging in first degree relatives of schizophrenia and bipolar disorder patients.Schizophrenia research · 2015Review
- Genetic underpinnings of white matter 'connectivity': heritability, risk, and heterogeneity in schizophrenia.Schizophrenia research · 2015Review
- Advances in neuroimaging research of schizophrenia in China.Shanghai archives of psychiatry · 2014Review
- Common variants in psychiatric risk genes predict brain structure at birth.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Oligodendrocyte genes, white matter tract integrity, and cognition in schizophrenia.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
- Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample.Schizophrenia research · 2013Article
- The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives.Translational psychiatry · 2012Article
- White matter integrity, language, and childhood onset schizophrenia.Schizophrenia research · 2012Article
- Functional and anatomical connectivity abnormalities in cognitive division of anterior cingulate cortex in schizophrenia.PloS one · 2012Article
- The effects of psychosis risk variants on brain connectivity: a review.Frontiers in psychiatry · 2012Article
- Neurocognitive-genetic and neuroimaging-genetic research paradigms in schizophrenia and bipolar disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2011Review
- Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population.Schizophrenia research · 2011Article
- White matter abnormalities and animal models examining a putative role of altered white matter in schizophrenia.Schizophrenia research and treatment · 2011Article
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuregulin1 (NRG1) influences the development of white matter connectivity and is implicated in genetic susceptibility to schizophrenia. The cingulum bundle is a white matter structure implicated in schizophrenia. Its anterior component is especially implicated, as it provides reciprocal connections between brain regions with prominent involvement in the disorder. Abnormalities in the structural integrity of the anterior cingulum in patients with schizophrenia have been reported previously. The present study investigated the potential contribution of NRG1 variation to anterior cingulum abnormalities in participants with schizophrenia.
methodsWe studied 31 men with schizophrenia and 36 healthy men using diffusion tensor imaging to investigate the association between fractional anisotropy in the anterior cingulum and a single-nucleotide polymorphism (SNP8NRG221533: rs35753505) of NRG1.
resultsConsistent with previous reports, fractional anisotropy was significantly reduced in the anterior cingulum in the schizophrenia group. Moreover, the results revealed a significant group (schizophrenia, control) by genotype (C/C, T carriers, including CT and TT) interaction between genetic variation in NRG1 and diagnosis of schizophrenia, such that the patients with the T allele for SNP8NRG221533 had significantly decreased anterior cingulum fractional anisotropy compared with patients homozygous for the C allele and healthy controls who were T carriers. LIMITATIONS: Limitations of our study included the small sample size of the TT subgroup and our use of only fractional anisotropy as an index of myelin integrity. In addition, the use of diffusion tensor imaging acquisition methods limited our ability to study other brain regions that may be involved in schizophrenia.
conclusionOur results suggest that NRG1 variation may play a role in the pathophysiology of anterior cingulum abnormalities in patients with schizophrenia.
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19448847PMC2674970W2126390643What OpenQuestion holds
Registered trials
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