ArticleNature neuroscience2009
Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells.
Article in Nature neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 89 citations in OpenAlex.
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- Spindle Orientation-Independent Control of Cell Fate Determination by RGS3 and KIF20A.Cerebral cortex communications · 2020Article
- Review
- Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis.Journal of cellular physiology · 2018Article
- Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities.International journal of molecular sciences · 2018Review
- Methyl 3,4-Dihydroxybenzoate Induces Neural Stem Cells to Differentiate Into Cholinergic NeuronsFrontiers in cellular neuroscience · 2018Article
- StableFrontiers in molecular neuroscience · 2018Article
- MAP6 interacts with Tctex1 and CaThe European journal of neuroscience · 2017Article
- Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation.PLoS genetics · 2017Article
- Extracellular Regulation of the Mitotic Spindle and Fate Determinants Driving Asymmetric Cell Division.Results and problems in cell differentiation · 2017Review
- Mutations in Citron Kinase Cause Recessive Microlissencephaly with Multinucleated Neurons.American journal of human genetics · 2016Article
- Aberrant Expression of Dynein light chain 1 (DYNLT1) is Associated with Human Male Factor Infertility.Molecular & cellular proteomics : MCP · 2015Article
- Novel insights into mammalian embryonic neural stem cell division: focus on microtubules.Molecular biology of the cell · 2015Article
- Sex- and tissue-specific methylome changes in brains of mice perinatally exposed to lead.Neurotoxicology · 2015Article
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6 authors at 2 institutions in 1 country.
Funding
Abstract
The mechanisms that regulate symmetric, proliferative divisions versus asymmetric, neurogenic divisions of mammalian neural precursors are still not well understood. We found that Lfc (Arhgef2), a Rho-specific guanine nucleotide exchange factor that interacts with spindle microtubules, and its negative regulator Tctex-1 (Dynlt1) determine the genesis of neurons from precursors in the embryonic murine cortex. Specifically, genetic knockdown of Arhgef2 in cortical precursors either in culture or in vivo inhibited neurogenesis and maintained cells as cycling radial precursors. Conversely, genetic knockdown of Dynlt1 in radial precursors promoted neurogenesis and depleted cycling cortical precursors. Coincident silencing of these two genes indicated that Tctex-1 normally inhibits the genesis of neurons from radial precursors by antagonizing the proneurogenic actions of Lfc. Moreover, Lfc and Tctex-1 were required to determine the orientation of mitotic precursor cell divisions in vivo. Thus, Lfc and Tctex-1 interact to regulate cortical neurogenesis, potentially by regulating mitotic spindle orientation.
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