ArticleNature genetics2009
Genetic variation in LIN28B is associated with the timing of puberty.
Article in Nature genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers, 10 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
189 citing papers in PubMed, 10 syntheses or guidelines pooled it, 382 citations in OpenAlex.
- Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene.Journal of human genetics · 2023Pooled it
- Age at menarche and epithelial ovarian cancer risk: A meta-analysis and Mendelian randomization study.Cancer medicine · 2019Pooled it
- Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.Nature neuroscience · 2019Pooled it
- Pooled it
- Age at menarche and endometrial cancer risk: a dose-response meta-analysis of prospective studies.Scientific reports · 2015Pooled it
- Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.Human molecular genetics · 2014Pooled it
- Genome-wide association study of age at menarche in African-American women.Human molecular genetics · 2013Pooled it
- An assessment of the individual and collective effects of variants on height using twins and a developmentally informative study design.PLoS genetics · 2011Pooled it
- LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer.Cancer research · 2011Pooled it
- Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.Nature genetics · 2010Pooled it
- Lin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer.The Journal of biological chemistry · 2012Trial
- Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty.Hormone research in paediatrics · 2012Trial
- CYP19A1 variation in healthy children: associations with breast development and pubertal gynecomastia.Endocrine connections · 2026Article
- let-7 miRNA and lin-46 mRNA are essential targets of the LIN28 RNA-binding protein in Caenorhabditis elegans developmental timing regulation.PLoS biology · 2026Article
- Heterokairic Genes and the Eco-Evo-Devo of Timing.Evolution & development · 2026Review
- Genetic insights into the relationship between age at menarche and mental health-related phenotypes.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Differential microRNA Expression Profiles in Girls with Idiopathic Central Precocious Puberty and Premature Thelarche.International journal of molecular sciences · 2026Article
- Genetic Perspective on the Relationship between Female Reproductive Traits, Exercise, and Bone Health Outcomes: Evidence from a National Database.Lifestyle genomics · 2026Article
- Testicular heterochrony in vgll3-mediated maturation age in Atlantic salmon.G3 (Bethesda, Md.) · 2025Article
- Genetic heritability of age at menarche and its association with early menopause in the Korean population: a secondary data analysis.Journal of Korean biological nursing science · 2025Article
129 more citing papers are in PubMed but not listed here.
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Authors and funding
35 authors at 15 institutions in 5 countries.
Funding
Abstract
The timing of puberty is highly variable. We carried out a genome-wide association study for age at menarche in 4,714 women and report an association in LIN28B on chromosome 6 (rs314276, minor allele frequency (MAF) = 0.33, P = 1.5 × 10(-8)). In independent replication studies in 16,373 women, each major allele was associated with 0.12 years earlier menarche (95% CI = 0.08-0.16; P = 2.8 × 10(-10); combined P = 3.6 × 10(-16)). This allele was also associated with earlier breast development in girls (P = 0.001; N = 4,271); earlier voice breaking (P = 0.006, N = 1,026) and more advanced pubic hair development in boys (P = 0.01; N = 4,588); a faster tempo of height growth in girls (P = 0.00008; N = 4,271) and boys (P = 0.03; N = 4,588); and shorter adult height in women (P = 3.6 × 10(-7); N = 17,274) and men (P = 0.006; N = 9,840) in keeping with earlier growth cessation. These studies identify variation in LIN28B, a potent and specific regulator of microRNA processing, as the first genetic determinant regulating the timing of human pubertal growth and development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.