ArticleNature genetics2009
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
Article in Nature genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 204 papers, 19 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
204 citing papers in PubMed, 19 syntheses or guidelines pooled it.
- Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene.Journal of human genetics · 2023Pooled it
- Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women.Human reproduction (Oxford, England) · 2022Pooled it
- Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.Nature communications · 2019Pooled it
- Genetic associations with age of menopause in familial longevity.Menopause (New York, N.Y.) · 2019Pooled it
- Age at menarche and epithelial ovarian cancer risk: A meta-analysis and Mendelian randomization study.Cancer medicine · 2019Pooled it
- Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.Nature communications · 2018Pooled it
- Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero.Human molecular genetics · 2018Pooled it
- Pooled it
- Recommendations for Premature Ovarian Insufficiency Surveillance for Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Report From the International Late Effects of Childhood Cancer Guideline Harmonization Group in Collaboration With the PanCareSurFup Consortium.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Guideline
- Age at menarche and endometrial cancer risk: a dose-response meta-analysis of prospective studies.Scientific reports · 2015Pooled it
- Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.Human molecular genetics · 2014Pooled it
- Meta-analysis of loci associated with age at natural menopause in African-American women.Human molecular genetics · 2014Pooled it
- Genome-wide association study of age at menarche in African-American women.Human molecular genetics · 2013Pooled it
- Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.American journal of epidemiology · 2013Pooled it
- A genome-wide association study of early menopause and the combined impact of identified variants.Human molecular genetics · 2013Pooled it
- Pooled it
- Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.Nature genetics · 2012Pooled it
- LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer.Cancer research · 2011Pooled it
- Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.Nature genetics · 2010Pooled it
- Gene variants associated with age at menopause are also associated with polycystic ovary syndrome, gonadotrophins and ovarian volume.Human reproduction (Oxford, England) · 2015Trial
144 more citing papers are in PubMed but not listed here.
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10 authors.
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Abstract
Age at menarche and age at natural menopause are associated with causes of substantial morbidity and mortality such as breast cancer and cardiovascular disease. We conducted a joint analysis of two genome-wide association studies of these two traits in a total of 17,438 women from the Nurses' Health Study (NHS, N = 2,287) and the Women's Genome Health Study (WGHS, N = 15,151). For age at menarche, we identified ten associated SNPs (P = 1 × 10(-7)-3 × 10(-13)) clustered at 6q21 (in or near the gene LIN28B) and 9q31.2 (in an intergenic region). For age at natural menopause, we identified 13 associated SNPs (P = 1 × 10(-7)-1 × 10(-21)) clustered at 20p12.3 (in the gene MCM8), 19q13.42 (in or near the gene BRSK1), 5q35.2 (in or near genes UIMC1 and HK3) and 6p24.2 (in the gene SYCP2L). These newly identified loci might expand understanding of the biological pathways regulating these two traits.
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