ArticleNature genetics2009
Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
Article in Nature genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
84 citing papers in PubMed, 9 syntheses or guidelines pooled it, 167 citations in OpenAlex.
- Pharmacogenomic studies of fertility outcomes in pediatric cancer survivors - A systematic review.Clinical and translational science · 2024Pooled it
- Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women.Human reproduction (Oxford, England) · 2022Pooled it
- Possible modification of BRSK1 on the risk of alkylating chemotherapy-related reduced ovarian function.Human reproduction (Oxford, England) · 2021Pooled it
- Genetic associations with age of menopause in familial longevity.Menopause (New York, N.Y.) · 2019Pooled it
- Pooled it
- Recommendations for Premature Ovarian Insufficiency Surveillance for Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Report From the International Late Effects of Childhood Cancer Guideline Harmonization Group in Collaboration With the PanCareSurFup Consortium.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Guideline
- Meta-analysis of loci associated with age at natural menopause in African-American women.Human molecular genetics · 2014Pooled it
- A genome-wide association study of early menopause and the combined impact of identified variants.Human molecular genetics · 2013Pooled it
- Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.Nature genetics · 2012Pooled it
- Gene variants associated with age at menopause are also associated with polycystic ovary syndrome, gonadotrophins and ovarian volume.Human reproduction (Oxford, England) · 2015Trial
- Trial
- Improving accuracy in genome-wide association studies: a two-step approach for handling below limit of detection biomarker measurements.NAR genomics and bioinformatics · 2025Article
- Studying ovarian aging and its health impacts: modern tools and approaches.Genes & development · 2025Review
- Genome-wide association and functional annotation analyses reveal candidate genes and pathways associated with various ewe longevity indicators in U.S. Katahdin sheep.Frontiers in genetics · 2025Article
- Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring.Nature aging · 2024Review
- Interindividual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors - a genome-wide association study: results from PanCareLIFE.Fertility and sterility · 2024Article
- Article
- Brain-specific serine/threonine-protein kinase 1 is a substrate of protein kinase C epsilon involved in sex-specific ethanol and anxiety phenotypes.Addiction biology · 2024Article
- No evidence for a diminished ovarian reserve among patients with hypertensive disorders of pregnancy: a case control study.Journal of ovarian research · 2024Observational
- Mechanisms of ovarian aging in women: a review.Journal of ovarian research · 2023Review
24 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors at 9 institutions in 2 countries.
Funding
Abstract
We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 × 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.