ReviewCurrent opinion in nephrology and hypertension2009
Do osteocytes contribute to phosphate homeostasis?
Review in Current opinion in nephrology and hypertension, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Sex specific effects of irisin on the skeleton.Bone research · 2026Review
- Targeting the mTOR-Autophagy Axis: Unveiling Therapeutic Potentials in Osteoporosis.Biomolecules · 2024Review
- Article
- Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner.bioRxiv : the preprint server for biology · 2024Article
- Osteoporosis: interferon-gamma-mediated bone remodeling in osteoimmunology.Frontiers in immunology · 2024Review
- Raised FGF23 Correlates to Increased Mortality in Critical Illness, Independent of Vitamin D.Biology · 2023Article
- Osteocyte-specific dentin matrix protein 1 : the role of mineralization regulation in low-magnitude high-frequency vibration enhanced osteoporotic fracture healing.Bone & joint research · 2022Article
- Effects of Extracellular Osteoanabolic Agents on the Endogenous Response of Osteoblastic Cells.Cells · 2021Review
- Bone metabolism and evolutionary origin of osteocytes: Novel application of FIB-SEM tomography.Science advances · 2021Article
- Phosphate Metabolism in Health and Disease.Calcified tissue international · 2021Review
- Article
- Role of αKlotho and FGF23 in regulation of type II Na-dependent phosphate co-transporters.Pflugers Archiv : European journal of physiology · 2019Review
- Role of phosphate sensing in bone and mineral metabolism.Nature reviews. Endocrinology · 2018Review
- Autophagy as a target for glucocorticoid-induced osteoporosis therapy.Cellular and molecular life sciences : CMLS · 2018Review
- Alpha Klotho and phosphate homeostasis.Journal of endocrinological investigation · 2014Review
- Glucocorticoid dose determines osteocyte cell fate.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Phosphorus metabolism in chronic kidney disease.Hippokratia · 2011Article
- FGF23 and the parathyroid glands.Pediatric nephrology (Berlin, Germany) · 2010Review
- DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
- Sclerostin antibody (Scl-Ab) improves osteomalacia phenotype in dentin matrix protein 1(Dmp1) knockout mice with little impact on serum levels of phosphorus and FGF23.Matrix biology : journal of the International Society for Matrix BiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Osteocytes, the terminally differentiated cell of the osteoblast lineage, account for over 90% of all bone cells. Due to their relative inaccessibility within mineralized matrix, little is known regarding their specific functions in comparison to the well studied surface bone cells, osteoblasts and osteoclasts. Furthermore, bone is often viewed as a mineral reservoir that passively releases calcium and phosphate in response to hormones secreted from remote organs. Noncollagenous matrix proteins produced in osteocytes, such as dentin matrix protein 1 (DMP1), have also been viewed as inert scaffolds for calcium-phosphate deposition. Recent discoveries of new genetic mutations in human diseases and development of genetically engineered animal models challenge these classic paradigms, suggesting that the osteocyte plays an active role in both mineralization and total systemic phosphate regulation. In this review, we will focus on roles of osteocytes in mineralization and particularly in phosphate regulation via the DMP1- FGF23 pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.