Evidence map›Paper›PMID 19448187›Full record

Trial reportThe American journal of psychiatry2009

Using neuroplasticity-based auditory training to improve verbal memory in schizophrenia.

Melissa Fisher, Christine Holland, Michael M Merzenich, Sophia Vinogradov

6 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 212 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
212citing papers in PubMed, 10 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01173874 phase3completednot on this mapstarted 2010, after this paper: background citation

Clinical and Biomarker Assessment of Efficacy of Cognitive Remediation in Patients With Schizophrenia or Schizoaffective Disorder Stabilized on Lurasidone

TypeinterventionalSponsorNew York State Psychiatric InstituteRan2010 to 2013Enrolled120ConditionsSchizophreniaArmsCognitive Remediation
NCT01550796 phase2completednot on this mapstarted 2012, after this paper: background citation

Treatment of Chronic Bothersome Tinnitus Using Cognitive Training and D-cycloserine

TypeinterventionalSponsorWashington University School of MedicineRan2012 to 2012Enrolled37ConditionsTinnitusArmsCognitive Training
NCT01772485 nacompletednot on this mapstarted 2013, after this paper: background citation

Double Blind Randomized Controlled Trial Evaluation of a Novel Brain Plasticity-based Training Program for the Remediation of Cognitive Deficits in Adolescents With ADHD in New Delhi, India

TypeinterventionalSponsorPosit Science CorporationRan2013 to 2015Enrolled31ConditionsAttention Deficit Hyperactivity DisorderArmsCognitive Training, Active Control
NCT01891721 nacompletednot on this mapstarted 2013, after this paper: background citation

Evaluating Two Types of Cognitive Training in Veterans With Schizophrenia

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2013 to 2018Enrolled105ConditionsSchizophreniaArmsBrain Fitness Program (BFP), Cognitive Package (Cogpack), Commercial Computer Games (Sporcle)
NCT02571504 nacompletednot on this mapstarted 2015, after this paper: background citation

Brain Imaging to Understand HIV-associated Neurocognitive Disorder and Predict Response to Cognitive Training

TypeinterventionalSponsorMcGill UniversityRan2015 to 2017Enrolled81ConditionsHIV - Human Immunodeficiency Virus, Cognitive ImpairmentArmsPlasticity-based Adaptive Cognitive Remediation (PACR)
NCT02634684 phase2completednot on this mapstarted 2014, after this paper: background citation

Pharmacologic Augmentation of Neurocognition and Cognitive Training in Psychosis

TypeinterventionalSponsorUniversity of California, San DiegoRan2014 to 2020Enrolled82ConditionsSchizophreniaArmsDextroamphetamine, Placebo
3 · Its place in the literature

Who cites it

212 citing papers in PubMed, 10 syntheses or guidelines pooled it, 421 citations in OpenAlex.

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  3. Video games for people with schizophrenia.The Cochrane database of systematic reviews · 2021
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152 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Melissa FisherDepartment of Psychiatry, UCSF/SFVAMC, Mail Code 116C, 4150 Clement St., San Francisco, CA 94121, USA.
Christine Holland
Michael M Merzenich
Sophia Vinogradov
University of California San Francisco Medical Center · US

Funding

Cognitive Remediation of Schizophrenia in a Community Mental Health SettingR01MH068725 · NIMH · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI VINOGRADOV, SOPHIA · 2004 to 2014
$4.9M
Brain-Plasticity Based Training for SchizophreniaR42MH073358 · NIMH · POSIT SCIENCE CORPORATION · PI MERZENICH, MICHAEL · 2005 to 2005
$140k
NIMH NIH HHS MH-068725NIMH NIH HHS R01 MH068725NIMH NIH HHS R42 MH-073358NIMH NIH HHS R42 MH073358
6 · The paper itself

Abstract

objectiveImpaired verbal memory in schizophrenia is a key rate-limiting factor for functional outcome, does not respond to currently available medications, and shows only modest improvement after conventional behavioral remediation. The authors investigated an innovative approach to the remediation of verbal memory in schizophrenia, based on principles derived from the basic neuroscience of learning-induced neuroplasticity. The authors report interim findings in this ongoing study.

methodFifty-five clinically stable schizophrenia subjects were randomly assigned to either 50 hours of computerized auditory training or a control condition using computer games. Those receiving auditory training engaged in daily computerized exercises that placed implicit, increasing demands on auditory perception through progressively more difficult auditory-verbal working memory and verbal learning tasks.

resultsRelative to the control group, subjects who received active training showed significant gains in global cognition, verbal working memory, and verbal learning and memory. They also showed reliable and significant improvement in auditory psychophysical performance; this improvement was significantly correlated with gains in verbal working memory and global cognition.

conclusionsIntensive training in early auditory processes and auditory-verbal learning results in substantial gains in verbal cognitive processes relevant to psychosocial functioning in schizophrenia. These gains may be due to a training method that addresses the early perceptual impairments in the illness, that exploits intact mechanisms of repetitive practice in schizophrenia, and that uses an intensive, adaptive training approach.

Indexed as

Auditory PerceptionMemoryRetention, PsychologyTeachingTherapy, Computer-AssistedVerbal BehaviorVerbal LearningAdultFemaleHumansMaleMemory DisordersNeuronal PlasticityQuality of LifeSchizophrenia

Identifiers

PMID19448187
PMCPMC2720319
OpenAlexW2168815652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.