ReviewThe Journal of experimental biology2009
Regulation of luminal acidification in the male reproductive tract via cell-cell crosstalk.
Review in The Journal of experimental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 128 citations in OpenAlex.
- Postnatal Cell Type- and Segment-Specific Localization of EGFR and Its Ligands (EGF, TGF-α, and AREG) in the Rat Epididymis.Anatomia, histologia, embryologia · 2026Article
- Extracellular Vesicles, Nutrient Balance, and Redox Metabolism During Epididymal Sperm Maturation: A Perspective on the Complexity of Intercellular Interplay.Advances in anatomy, embryology, and cell biology · 2026Review
- First Evidence of Siglec-10 Localization and Expression in Camel Male Reproductive Tissues and Spermatozoa: Potential Relevance to Fertility.Veterinary sciences · 2025Article
- Metabolomic Analysis of Cauda Epididymal Fluid in Yaks and Cattle.Animals : an open access journal from MDPI · 2025Article
- The Microenvironment in Focus for Male Fertility.Function (Oxford, England) · 2025Article
- Ovochymase 2 is a key regulatory factor modulating proteolytic pathways and sperm maturation in the mammalian epididymis†.Biology of reproduction · 2025Article
- Sacrificing cells of the cyst: non-apoptotic cell death in germline cysts via acidification.Frontiers in cell death · 2025Article
- Bovine Sperm Maturation.Advances in anatomy, embryology, and cell biology · 2025Review
- Identification of hub genes associated with decreased fertility in male mice of advanced paternal age.Frontiers in cell and developmental biology · 2025Article
- Pulmonary Arterial Hypertension Affects Sperm Quality and Epididymis Function in Sedentary and Exercised Wistar Rats.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Recent advances in acid sensing by G protein coupled receptors.Pflugers Archiv : European journal of physiology · 2024Review
- The significance of single-cell transcriptome analysis in epididymis research.Frontiers in cell and developmental biology · 2024Article
- Article
- Polarized epithelium-sperm co-culture system reveals stimulatory factors for the secretion of mouse epididymal quiescin sulfhydryl oxidase 1.The Journal of reproduction and development · 2022Article
- Differential expression and localization of tight junction proteins in the goat epididymis.Journal of animal science and technology · 2022Article
- Cystic Fibrosis and the Cells of the Airway Epithelium: What Are Ionocytes and What Do They Do?Annual review of pathology · 2022Review
- Vacuolar H(+)-ATPase is not restricted to clear cells of the epididymal epithelium in cattle.Journal of animal science and technology · 2021Article
- The HAmerican journal of physiology. Cell physiology · 2021Review
- Morphology and immunolocalization of aquaporins 1 and 9 in the agouti (Animal reproduction · 2021Article
- Regulation and function of V-ATPases in physiology and disease.Biochimica et biophysica acta. Biomembranes · 2020Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In the epididymis, spermatozoa acquire their ability to become motile and to fertilize an egg. A luminal acidic pH and a low bicarbonate concentration help keep spermatozoa in a quiescent state during their maturation and storage in this organ. Net proton secretion is crucial to maintain the acidity of the luminal fluid in the epididymis. A sub-population of epithelial cells, the clear cells, express high levels of the proton-pumping V-ATPase in their apical membrane and are important contributors to luminal acidification. This review describes selected aspects of V-ATPase regulation in clear cells. The assembly of a particular set of V-ATPase subunit isoforms governs the targeting of the pump to the apical plasma membrane. Regulation of V-ATPase-dependent proton secretion occurs via recycling mechanisms. The bicarbonate-activated adenylyl cyclase is involved in the non-hormonal regulation of V-ATPase recycling, following activation of bicarbonate secretion by principal cells. The V-ATPase is also regulated in a paracrine manner by luminal angiotensin II by activation of the angiotensin II type 2 receptor (AGTR2), which is located in basal cells. Basal cells have the remarkable property of extending long and slender cytoplasmic projections that cross the tight junction barrier to monitor the luminal environment. Clear cells are activated by a nitric oxide signal that originates from basal cells. Thus, a complex interplay between the different cell types present in the epithelium leads to activation of the luminal acidifying capacity of the epididymis, a process that is crucial for sperm maturation and storage.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.