ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2009
Functional neurons and melanocytes induced from immortal lines of postnatal neural crest-like stem cells.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Electrochemical imaging of neurotransmitter release with fast-scan voltammetric ion conductance microscopy.Science advances · 2024Article
- New Insights into TRP Ion Channels in Stem Cells.International journal of molecular sciences · 2022Review
- Inhibition of Fam114A1 protects melanocytes from apoptosis through higher RACK1 expression.Aging · 2021Article
- Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter.Stem cell research & therapy · 2020Article
- Isolation and Characterization of Neural Crest-Derived Stem Cells From Adult Ovine Palatal Tissue.Frontiers in cell and developmental biology · 2018Article
- Isolating primary melanocyte-like cells from the mouse heart.Journal of visualized experiments : JoVE · 2014Article
- miR-21 promotes the differentiation of hair follicle-derived neural crest stem cells into Schwann cells.Neural regeneration research · 2014Article
- Premature graying as a consequence of compromised antioxidant activity in hair bulb melanocytes and their precursors.PloS one · 2014Article
- The transient receptor potential channel TRPA1: from gene to pathophysiology.Pflugers Archiv : European journal of physiology · 2012Review
- Detailed histological structure of human hair follicle bulge region at different ages: a visible niche for nesting adult stem cells.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2012Article
- Targeting protein-trafficking pathways alters melanoma treatment sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Regulation of apoptosis in human melanoma and neuroblastoma cells by statins, sodium arsenite and TRAIL: a role of combined treatment versus monotherapy.Apoptosis : an international journal on programmed cell death · 2011Article
- The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin.Pigment cell & melanoma research · 2011Review
- Primary culture of chick, mouse or human neural crest cells.Nature protocols · 2011Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Stem cells, that is, cells that can both reproduce themselves and differentiate into functional cell types, attract much interest as potential aids to healing and disease therapy. Embryonic neural crest is pluripotent and generates the peripheral nervous system, melanocytes, and some connective tissues. Neural-crest-related stem cells have been reported previously in postnatal skin: committed melanocytic stem cells in the hair follicle, and pluripotent cell types from the hair follicle and papilla that can produce various sets of lineages. Here we describe novel pluripotent neural crest-like stem cells from neonatal mouse epidermis, with different potencies, isolated as 3 independent immortal lines. Using alternative regulatory factors, they could be converted to large numbers of either Schwann precursor cells, pigmented melanocytes, chondrocytes, or functional sensory neurons showing voltage-gated sodium channels. Some of the neurons displayed abundant active TRPV1 and TRPA1 receptors. Such functional neurons have previously been obtained in culture only with difficulty, by explantation. The system was also used to generate comparative gene expression data for the stem cells, melanocytes, and melanoblasts that sufficiently explain the lack of pigment in melanoblasts and provide a rationale for some genes expressed apparently ectopically in melanomas, such as ephrin receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.