Trial reportDrug and alcohol dependence2009
Prefrontal cognitive dysfunction is associated with tobacco dependence treatment failure in smokers with schizophrenia.
Trial report in Drug and alcohol dependence, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01465074 (Effects of Acute Nicotine on Long-term Potentiation in the Dorsolateral Prefrontal Cortex of Patients With Schizophrenia and Healthy Controls), which is not on this map. Cited by 27 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Acute Nicotine on Long-term Potentiation in the Dorsolateral Prefrontal Cortex of Patients With Schizophrenia and Healthy Controls
Who cites it
27 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2020Pooled it
- Pharmacotherapy for smoking cessation in schizophrenia: a systematic review.Expert opinion on pharmacotherapy · 2020Pooled it
- Efficacy and tolerability of pharmacotherapy for smoking cessation in adults with serious mental illness: a systematic review and network meta-analysis.Addiction (Abingdon, England) · 2016Pooled it
- Antidepressants for cognitive impairment in schizophrenia--a systematic review and meta-analysis.Schizophrenia research · 2014Pooled it
- Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2014Pooled it
- Interventions for smoking cessation and reduction in individuals with schizophrenia.The Cochrane database of systematic reviews · 2013Pooled it
- Executive function fails to predict smoking outcomes in a clinical trial to motivate smokers to quit.Drug and alcohol dependence · 2017Trial
- Abstinence and Use of Community-Based Cessation Treatment After a Motivational Intervention Among smokers with Severe Mental Illness.Community mental health journal · 2016Trial
- Effects of varenicline and bupropion on cognitive processes among nicotine-deprived smokers.Experimental and clinical psychopharmacology · 2012Trial
- The role of executive functioning in smoking cessation: A scoping review.Drug and alcohol review · 2025Article
- Changes in distinct brain systems identified with fMRI during smoking cessation treatment with varenicline: a review.Psychopharmacology · 2024Review
- Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2023Review
- Neurocognitive moderation of repetitive transcranial magnetic stimulation (rTMS) effects on cannabis use in schizophrenia: a preliminary analysis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Palliative and high-intensity end-of-life care in schizophrenia patients with lung cancer: results from a French national population-based study.European archives of psychiatry and clinical neuroscience · 2021Article
- Brief, Web-Based Interventions to Motivate Smokers With Schizophrenia: Randomized Trial.JMIR mental health · 2020Article
- Review of pharmacotherapy for smoking cessation in patients with schizophrenia.The mental health clinician · 2018Review
- Predictors of tobacco abstinence in outpatient smokers with schizophrenia or bipolar disorder treated with varenicline and cognitive behavioral smoking cessation therapy.Addictive behaviors · 2017Article
- Smoking cessation and reduction in people with chronic mental illness.BMJ (Clinical research ed.) · 2015Review
- Effects of smoking abstinence on cigarette craving, nicotine withdrawal, and nicotine reinforcement in smokers with and without schizophrenia.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2014Article
- Cognitive function during nicotine withdrawal: Implications for nicotine dependence treatment.Neuropharmacology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundPatients with schizophrenia have higher rates of smoking (58-88%) than in the general population ( approximately 22%), and are more refractory to smoking cessation. These patients also exhibit numerous neurocognitive deficits, some of which may be ameliorated by cigarette smoking. The neurocognitive benefits derived from nicotine may, in turn, contribute to elevated rates of smoking and smoking persistence in schizophrenia. The present study examined the relationship between neurocognitive function and smoking cessation in schizophrenia.
methodsTreatment-seeking smokers with schizophrenia (N=58) participated in a 10-week placebo-controlled trial of sustained-release (SR) bupropion plus transdermal nicotine patch. Neuropsychological performance was evaluated in a subset of patients (n=31), prior to pharmacological treatment, using a neurocognitive battery.
resultsSubjects were compared as a function of endpoint smoking status (Quit versus Not Quit), assessed by end of trial 7-day point prevalence abstinence, confirmed by CO level (< 10 ppm) on demographic traits, smoking, and clinical outcomes. While there were no significant baseline differences between quitters and non-quitters, non-quitters exhibited significantly greater deficits in performance on Trail Making Test, Part B (p=0.01) and on Digit Span backwards (p=0.04) compared to quitters. No associations were found between quit status and performance on other neuropsychological measures.
conclusionsOur findings extend results of previous studies which suggest deficits in frontal executive function are associated with smoking cessation failure in schizophrenia. This may have implications for the development of tailored smoking cessation treatments in this population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.