ReviewPeptides2009
Animals models of MCH function and what they can tell us about its role in energy balance.
Review in Peptides, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Melanin-Concentrating Hormone (MCH): Role in Mediating Reward-Motivated and Emotional Behavior and the Behavioral Disturbances Produced by Repeated Exposure to Reward Substances.International journal of molecular sciences · 2025Review
- Glutamatergic signaling from melanin-concentrating hormone-producing neurons: A requirement for memory regulation, but not for metabolism control.PNAS nexus · 2024Article
- Roles of Neuropeptides in Sleep-Wake Regulation.International journal of molecular sciences · 2022Review
- Conditional deletion of melanin-concentrating hormone receptor 1 from GABAergic neurons increases locomotor activity.Molecular metabolism · 2019Article
- Obesity: Current and potential pharmacotherapeutics and targets.Pharmacology & therapeutics · 2017Review
- Evolution, immunity and the emergence of brain superautoantigens.F1000Research · 2017Article
- The melanin-concentrating hormone receptors: neuronal and non-neuronal functions.International journal of obesity supplements · 2014Review
- Inflammation-induced functional connectivity of melanin-concentrating hormone and IL-10.Peptides · 2014Article
- Acute escitalopram treatment inhibits REM sleep rebound and activation of MCH-expressing neurons in the lateral hypothalamus after long term selective REM sleep deprivation.Psychopharmacology · 2013Article
- Animal models in obesity and hypertension.Current hypertension reports · 2013Review
- Pmch-deficiency in rats is associated with normal adipocyte differentiation and lower sympathetic adipose drive.PloS one · 2013Article
- Control of ventricular ciliary beating by the melanin concentrating hormone-expressing neurons of the lateral hypothalamus: a functional imaging survey.Frontiers in endocrinology · 2013Article
- Peripheral injections of melanin-concentrating hormone receptor 1 antagonist S38151 decrease food intake and body weight in rodent obesity models.Frontiers in endocrinology · 2012Article
- Molecular basis of the obesity associated with Bardet-Biedl syndrome.Trends in endocrinology and metabolism: TEM · 2011Review
- Age-related loss of orexin/hypocretin neurons.Neuroscience · 2011Article
- Two naturally occurring mutations in the type 1 melanin-concentrating hormone receptor abolish agonist-induced signaling.The Journal of pharmacology and experimental therapeutics · 2010Article
- A comparative analysis shows morphofunctional differences between the rat and mouse melanin-concentrating hormone systems.PloS one · 2010Article
- Leptin receptor modulation of adiposity and fertility.Trends in endocrinology and metabolism: TEM · 2010Review
- The metabolic phenotype of SCD1-deficient mice is independent of melanin-concentrating hormone.Peptides · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Melanin-concentrating hormone (MCH) has attracted considerable attention because of its effects on food intake and body weight and the MCH receptor (MCHR1) remains one of the viable targets for obesity therapy. This review summarizes the literature examining the effects of MCH on body weight, food intake and energy expenditure in rodent models, and the central sites where MCH acts in regulating energy homeostasis. Emphasis is given on the discrepancies between the genetic and pharmacologic models of MCHR1 inactivation. We propose some solutions to resolve these discrepancies and discuss some future directions in MCH research.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.