Evidence map›Paper›PMID 19447085›Full record

ArticleNeuron2009

Rethinking how hearing happens.

Zhigang Xu, Anthony J Ricci, Stefan Heller

Abstract readComment
In one paragraph

Article in Neuron, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Liquid-liquid phase separation in hair cell stereocilia development and maintenance.Computational and structural biotechnology journal · 2023
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Zhigang XuOtolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Anthony J Ricci
Stefan Heller

Funding

Tonotopic variations in mechano-electric transductionR01DC003896 · NIDCD · STANFORD UNIVERSITY · PI RICCI, ANTHONY J · 1999 to 2022
$11.1M
Molecular Mechanisms of Inner Ear FunctionR01DC004563 · NIDCD · STANFORD UNIVERSITY · PI HELLER, STEFAN · 2001 to 2014
$5.1M
NIDCD NIH HHS R01 DC003896NIDCD NIH HHS R01 DC004563
6 · The paper itself

Abstract

Inner ear hair cells convert hair bundle deflection into mechanical force sensed by ion channels via extracellular tip links between adjacent stereocilia. In this Neuron issue, Grillet and colleagues show the protein harmonin mechanically reinforces tip link upper insertion sites. Harmonin loss at this site reduces mechanotransduction kinetics and sensitivity.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCell Cycle ProteinsCell Surface ExtensionsCytoskeletal ProteinsHair Cells, Auditory, InnerHearingHumansMechanotransduction, CellularModels, BiologicalAdaptor Proteins, Signal TransducingCell Cycle ProteinsCytoskeletal ProteinsUSH1C protein, human

Identifiers

PMID19447085
PMCPMC3246801

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.