ArticleNeuroscience letters2009
A preliminary study of functional connectivity in comorbid adolescent depression.
Article in Neuroscience letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
131 citing papers in PubMed, 7 syntheses or guidelines pooled it, 230 citations in OpenAlex.
- Structural, functional, and metabolic signatures of postpartum depression: A systematic review.Frontiers in psychiatry · 2022Pooled it
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Abnormal amygdala resting-state functional connectivity in adults and adolescents with major depressive disorder: A comparative meta-analysis.EBioMedicine · 2018Pooled it
- Adolescent brain development and depression: A case for the importance of connectivity of the anterior cingulate cortex.Neuroscience and biobehavioral reviews · 2016Pooled it
- Large-Scale Network Dysfunction in Major Depressive Disorder: A Meta-analysis of Resting-State Functional Connectivity.JAMA psychiatry · 2015Pooled it
- Functional brain imaging studies of youth depression: a systematic review.NeuroImage. Clinical · 2014Pooled it
- Toward dysfunctional connectivity: a review of neuroimaging findings in pediatric major depressive disorder.Brain imaging and behavior · 2011Pooled it
- Intrinsic functional connectivity predicts remission on antidepressants: a randomized controlled trial to identify clinically applicable imaging biomarkers.Translational psychiatry · 2018Trial
- Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents.EBioMedicine · 2017Trial
- Local and Global Resting State Activity in the Noradrenergic and Dopaminergic Pathway Modulated by Reboxetine and Amisulpride in Healthy Subjects.The international journal of neuropsychopharmacology · 2015Trial
- Dysfunction of affective network in post ischemic stroke depression: a resting-state functional magnetic resonance imaging study.BioMed research international · 2014Trial
- Antidepressant medications reduce subcortical-cortical resting-state functional connectivity in healthy volunteers.NeuroImage · 2011Trial
- Neuroanatomical and Functional Correlates in Depressive Spectrum: A Narrative Review.Journal of personalized medicine · 2025Review
- Abnormal Structure-Function Coupling in Major Depressive Disorder Patients With and Without Anhedonia.Depression and anxiety · 2025Article
- Disruption of Multimodal Brain Networks and Structural-Functional Coupling in Adolescents with Major Depressive Disorder.Neuropsychiatric disease and treatment · 2025Article
- Article
- Strength and resilience of developing brain circuits predict adolescent emotional and stress responses during the COVID-19 pandemic.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A study on the association between prefrontal functional connectivity and non-suicidal self-injury in adolescents with depression.Frontiers in neurology · 2024Article
- Altered task-related decoupling of the rostral anterior cingulate cortex in depression.NeuroImage. Clinical · 2024Article
- Dynamic network characteristics of adolescents with major depressive disorder: Attention network mediates the association between anhedonia and attentional deficit.Human brain mapping · 2023Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Major depressive disorder (MDD) begins frequently in adolescence and is associated with severe outcomes, but the developmental neurobiology of MDD is not well understood. Research in adults has implicated fronto-limbic neural networks in the pathophysiology of MDD, particularly in relation to the subgenual anterior cingulate cortex (ACC). Developmental changes in brain networks during adolescence highlight the need to examine MDD-related circuitry in teens separately from adults. Using resting state functional magnetic resonance imaging (fMRI), this study examined functional connectivity in adolescents with MDD (n=12) and healthy adolescents (n=14). Seed-based connectivity analysis revealed that adolescents with MDD have decreased functional connectivity in a subgenual ACC-based neural network that includes the supragenual ACC (BA 32), the right medial frontal cortex (BA 10), the left inferior (BA 47) and superior frontal cortex (BA 22), superior temporal gyrus (BA 22), and the insular cortex (BA 13). These preliminary data suggest that MDD in adolescence is associated with abnormal connectivity within neural circuits that mediate emotion processing. Future research in larger, un-medicated samples will be necessary to confirm this finding. We conclude that hypothesis-driven, seed-based analyses of resting state fMRI data hold promise for advancing our current understanding of abnormal development of neural circuitry in adolescents with MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.