ArticleAnnals of general psychiatry2009
Schizophrenia pathophysiology: are we any closer to a complete model?
Article in Annals of general psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 33 citations in OpenAlex.
- Schizophrenia and Rheumatoid Arthritis Genetic Scenery: Potential Non-HLA Genes Involved in Both Diseases Relationship.The Yale journal of biology and medicine · 2024Article
- Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review.AIMS neuroscience · 2024Review
- Elucidating salient site-specific functional connectivity features and site-invariant biomarkers in schizophrenia via deep neural networks.Scientific reports · 2023Article
- Review
- Tetrahydrobiopterin and Its Multiple Roles in Neuropsychological Disorders.Neurochemical research · 2022Review
- Articulating biological and social approaches in child and adolescent psychiatry.Frontiers in child and adolescent psychiatry · 2022Article
- Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk.JAMA psychiatry · 2019Article
- Clinicopathological Study of Patients With C9ORF72-Associated Frontotemporal Dementia Presenting With Delusions.Journal of geriatric psychiatry and neurology · 2015Article
- Mass spectrometric analysis of prefrontal cortex proteins in schizophrenia and bipolar disorder.SpringerPlus · 2012Article
- Biomarkers in psychiatry: drawbacks and potential for misuse.International archives of medicine · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia, a severe brain disorder that involves hallucinations, disordered thinking and deficiencies in cognition, has been studied for decades in order to determine the early events that lead to this neurological disorder. In this review, we interpret the developmental and genetic models that have been proposed and treatment options associated with these models. Schizophrenia was initially thought to be hereditary based on studies of high incidence in certain families. Additionally, studies on specific genes such as ZDHHC8 and DTNBP1 seem to suggest susceptibility to the onset of this disorder. However, no single gene variation has been linked to schizophrenia, and recent evidence on sporadic cases of schizophrenia refutes genetics as being a singular cause of the disease. In addition, current data suggests neurodevelopmental or environmental causes such as viral infections and prenatal/perinatal complications. Before any brain disorder can be understood, however, multiple cognitive neuroscientific models that accommodate evidence from many biomedical research fields should be considered, and unfortunately, many of these models are in the earliest stages of development. Consequently, it makes us question whether we are any closer to an adequate understanding of the pathophysiology of schizophrenia.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.