ArticleNeuroscience letters2009
Osmolality-induced tuning of action potentials in trigeminal ganglion neurons.
Article in Neuroscience letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Influence of Impaired Hydration Status on Postoperative in-Hospital Death in Patients with Acute Type A Aortic Dissection.International journal of general medicine · 2023Article
- Association Between Serum Sodium and Long-Term Mortality in Critically Ill Patients with Comorbid Chronic Obstructive Pulmonary Disease: Analysis from the MIMIC-IV Database.International journal of chronic obstructive pulmonary disease · 2022Article
- Induced hypernatremia in patients with moderate-to-severe ARDS: a randomized controlled study.Intensive care medicine experimental · 2021Article
- Article
- AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage.APL bioengineering · 2019Article
- Regulation of Pain and Itch by TRP Channels.Neuroscience bulletin · 2018Review
- Hepatic and renal mechanisms underlying the osmopressor response.Autonomic neuroscience : basic & clinical · 2017Article
- Transient Receptor Potential Vanilloid 4 Inhibits γ-Aminobutyric Acid-Activated Current in Hippocampal Pyramidal Neurons.Frontiers in molecular neuroscience · 2016Article
- Transient Receptor Potential Vanilloid 4-Induced Modulation of Voltage-Gated Sodium Channels in Hippocampal Neurons.Molecular neurobiology · 2016Article
- Hyperosmolar tears enhance cooling sensitivity of the corneal nerves in rats: possible neural basis for cold-induced dry eye pain.Investigative ophthalmology & visual science · 2014Article
- Transient receptor potential vanilloid 4 mediates hypotonicity-induced enhancement of synaptic transmission in hippocampal slices.CNS neuroscience & therapeutics · 2013Article
- Effect of the TRPV1 antagonist SB-705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig.British journal of pharmacology · 2013Article
- Novel insights into TRPV4 function in the kidney.Pflugers Archiv : European journal of physiology · 2013Review
- 4α-phorbol 12,13-didecanoate activates cultured mouse dorsal root ganglia neurons independently of TRPV4.British journal of pharmacology · 2013Article
- Hypotonicity modulates tetrodotoxin-sensitive sodium current in trigeminal ganglion neurons.Molecular pain · 2011Article
- Avian magnetite-based magnetoreception: a physiologist's perspective.Journal of the Royal Society, Interface · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The present study explored the effect of anisotonicity on action potential (AP) in cultured trigeminal ganglion (TG) neurons. We demonstrate that the number of evoked APs was increased by both hypo- and hypertonic treatment. Transient Receptor Potential Vanilloid 4 receptor (TRPV4) activator increased the number of APs, but only hypotonic-response was markedly blocked in TRPV4-/- mice. Additionally, inhibition of PKC attenuated hypotonicity-induced increase, whereas antagonism of PKA attenuated hypertonicity-response. We conclude that anisotonicity increases excitability of nociceptors, which might be involved in anisotonicity-induced nociception. The increase of APs by hypo- and hypertonicity is mediated through different receptor and intracellular signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.