Evidence map›Paper›PMID 19444841›Full record

ArticleAngewandte Chemie (International ed. in English)2009

Efficient replication bypass of size-expanded DNA base pairs in bacterial cells.

James C Delaney, Jianmin Gao, Haibo Liu, Nidhi Shrivastav, John M Essigmann, Eric T Kool

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 58 citations in OpenAlex.

  1. Recognition-Encoded Molecules: A Minimal Self-Replicator.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Artificial genetic sets composed of size-expanded base pairs.Angewandte Chemie (International ed. in English) · 2013
    Review
  14. DNA-multichromophore systems.Chemical reviews · 2012
    Review
  15. Encoding phenotype in bacteria with an alternative genetic set.Journal of the American Chemical Society · 2011
    Article
  16. Chemistry of nucleic acids: impacts in multiple fields.Chemical communications (Cambridge, England) · 2011
    Review
  17. Article
  18. Article
  19. Article
  20. Non-natural nucleic acids for synthetic biology.Current opinion in chemical biology · 2009
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

James C DelaneyDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jianmin Gao
Haibo Liu
Nidhi Shrivastav
John M Essigmann
Eric T Kool
Massachusetts Institute of Technology · USStanford University · US

Funding

Intra and Extra-Chromosomal Probes for Mutagenesis by CarcinogensR01CA080024 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1998 to 2025
$5.9M
Intra- and Extra-Chromosomal Probes for Mutagenesis by CarcinogensR37CA080024 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 2008 to 2015
$3.1M
Mechanistic Comparison of Cisplatin with Synthetic DNA Repair-Shielding AnticanceR01CA086061 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 2000 to 2010
$2.9M
RE-ENGINEERING THE DIAMETER OF THE DOULBE HELIXR01GM063587 · NIGMS · STANFORD UNIVERSITY · PI KOOL, ERIC T. · 2001 to 2010
$2.2M
NCI NIH HHS CA80024NCI NIH HHS R01 CA080024NCI NIH HHS R01 CA086061NCI NIH HHS R37 CA080024NIGMS NIH HHS GM63587NIGMS NIH HHS R01 GM063587
6 · The paper itself

Abstract

Supersize me! Size-expanded DNA bases (xDNA) are able to encode natural DNA sequences in replication. In vitro experiments with a DNA polymerase show nucleotide incorporation opposite the xDNA bases with correct pairing. In vivo experiments using E. coli show that two xDNA bases (xA and xC, see picture) encode the correct replication partners.

Indexed as

DNA ReplicationBase PairingDNADNA-Directed DNA PolymeraseEscherichia coliKineticsNucleotidesDNADNA-Directed DNA PolymeraseNucleotides

Identifiers

PMID19444841
PMCPMC3434874
OpenAlexW2141733565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.