ArticleUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2009
Can prenatal ultrasound detect the effects of in-utero alcohol exposure? A pilot study.
Article in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- The Association of Prenatal Alcohol Exposure With Brain Development During the First 1000 Days of Life: A Systematic Review.Prenatal diagnosis · 2024Pooled it
- A systematic review of maternal smoking during pregnancy and fetal measurements with meta-analysis.PloS one · 2017Pooled it
- Alcohol exposure before and during pregnancy is associated with reduced fetal growth: the Safe Passage Study.BMC medicine · 2023Article
- The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities.IBRO neuroscience reports · 2022Review
- Drowning our sorrows: clinical and ethical considerations of termination in alcohol-affected pregnancy.BMC pregnancy and childbirth · 2020Article
- Maternal choline supplementation mitigates alcohol-induced fetal cranio-facial abnormalities detected using an ultrasonographic examination in a sheep model.Alcohol (Fayetteville, N.Y.) · 2019Article
- Asymmetric neonatal spasms as an early sign of brain malformation potentially caused by regular light alcohol consumption during the first 22 weeks of pregnancy, a clinical case report.Developmental period medicine · 2019Article
- Maternal exposure to ambient air pollution and fetal growth in North-East Scotland: A population-based study using routine ultrasound scans.Environment international · 2017Article
- Cardiac Orienting Responses Differentiate the Impact of Prenatal Alcohol Exposure in Ukrainian Toddlers.Alcoholism, clinical and experimental research · 2016Article
- Second-Trimester Ultrasound as a Tool for Early Detection of Fetal Alcohol Spectrum Disorders.Alcoholism, clinical and experimental research · 2016Article
- Fetal alcohol-spectrum disorders: identifying at-risk mothers.International journal of women's health · 2016Review
- Dysmorphogenic effects of first trimester-equivalent ethanol exposure in mice: a magnetic resonance microscopy-based study.Alcoholism, clinical and experimental research · 2014Article
- Fetal alcohol spectrum disorders and neuroimmune changes.International review of neurobiology · 2014Review
- Ethanol exposure during pregnancy persistently attenuates cranially directed blood flow in the developing fetus: evidence from ultrasound imaging in a murine second trimester equivalent model.Alcoholism, clinical and experimental research · 2012Article
- Magnetic resonance-based imaging in animal models of fetal alcohol spectrum disorder.Neuropsychology review · 2011Review
- Focus on: magnetic resonance-based studies of fetal alcohol spectrum disorders in animal models.Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2011Review
- Magnetic resonance microscopy-based analyses of the brains of normal and ethanol-exposed fetal mice.Birth defects research. Part A, Clinical and molecular teratology · 2010Article
- Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 7.Alcoholism, clinical and experimental research · 2010Article
- Effects of medications for opioid use disorder (MOUD) on fetal brain and cranial measurements.Neurotoxicology and teratologyArticle
- Magnetic resonance microscopy-based analyses of the neuroanatomical effects of gestational day 9 ethanol exposure in mice.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesThe aim of this pilot study was to explore possible ultrasound parameters for the early detection of alcohol-mediated fetal somatic and central nervous system (CNS) maldevelopment. Maternal alcohol ingestion during pregnancy may lead to fetal alcohol spectrum disorders (FASD), which encompass a broad range of structural abnormalities including growth impairment, specific craniofacial features and CNS abnormalities. Early detection of fetuses at risk of FASD would support earlier interventions.
methodsWe performed a longitudinal prospective pilot study from 2004 to 2006 at two sites in Ukraine. A sample of pregnant women who reported consuming moderate-to-heavy amounts of alcohol participated in a comprehensive maternal interview, and received ultrasound evaluation of fetal growth and specific fetal brain measurements during the second and third trimesters. These measurements were compared with those collected from a group of pregnant women who consumed little-to-no alcohol during pregnancy, and who were recruited and followed in the same manner.
resultsFrom 6745 screened women, 84 moderate-to-heavy alcohol users and 82 comparison women were identified and ultrasound examinations performed. After controlling for maternal smoking, alcohol-exposed fetuses had shorter mean femur length, caval-calvarial distance and frontothalamic measurements in the second trimester (P < 0.05), and alcohol-exposed fetuses also had shorter frontothalamic distance measurements in the third trimester relative to comparison fetuses (P < 0.05). In addition, after controlling for maternal smoking, both mean orbital diameter and biparietal diameter measurements were significantly smaller on average in the alcohol-exposed group in the third trimester relative to comparison fetuses (P < 0.05).
conclusionsSignificant differences in selected somatic and brain measurements were noted between alcohol-exposed and comparison fetuses, suggesting these markers may be further explored for clinical utility in prenatal identification of affected children. Further study correlating these findings with alcohol-related physical features of the newborn and subsequent comparisons of neuro-developmental outcomes will help define potential uses of prenatal ultrasound for intervention and prevention of FASD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.