Evidence map›Paper›PMID 19444675›Full record

ArticleAIDS care2009

HAART receipt and viral suppression among HIV-infected patients with co-occurring mental illness and illicit drug use.

Geetanjali Chander, Seth Himelhoch, John A Fleishman, James Hellinger, Paul Gaist, Richard D Moore, Kelly A Gebo

Registry-linked trialOpen access · greenAbstract readComparative StudyMulticenter Study
In one paragraph

Article in AIDS care, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04601064 (Peer Supported Collaborative Care to Increase Engagement in Mental Health and Substance Use Disorder Care in HIV Care Settings), which is not on this map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04601064 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Peer Supported Collaborative Care to Increase Engagement in Mental Health and Substance Use Disorder Care in HIV Care Settings

TypeinterventionalSponsorJohns Hopkins UniversityRan2022 to 2026Enrolled405ConditionsHIV Infections, Substance Use Disorders, Mental Health Disorder, AddictionArmsCollaborative Care Model
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 57 citations in OpenAlex.

  1. Trial
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  4. Inflammasomes as mediators of inflammation in HIV-1 infection.Translational research : the journal of laboratory and clinical medicine · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Geetanjali ChanderDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. GChande1@jhmi.edu
Seth Himelhoch
John A Fleishman
James Hellinger
Paul Gaist
Richard D Moore
Kelly A Gebo
Johns Hopkins Medicine · USAgency for Healthcare Research and Quality · USJohns Hopkins University · USNational Institutes of Health · USTufts Medical Center · USUniversity of Maryland, Baltimore · US

Funding

North American AIDS Cohorts on Collaboration and Design (NAACCORD)U01AI069918 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Keri Nicole Althoff, RICHARD Douglas MOORE · 2006 to 2026
$65.2M
Johns Hopkins HIV Clinical CohortU01DA036935 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2014 to 2024
$14.9M
MID CAREER INVESTIGATOR AWARDK24DA000432 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2000 to 2009
$1.5M
HIV Care for Substance Users with Psychiatric DisordersK23DA019820 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI HIMELHOCH, SETH S · 2005 to 2009
$883k
Alcohol and Psychiatric Comorbidity in HIV+ WomenK23AA015313 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI CHANDER, GEETANJALI · 2005 to 2009
$875k
IMPROVING HEALTH CARE UTILIZATION IN HIV+ DRUG USERSK23DA000523 · NIDA · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2001 to 2005
$794k
NIAAA NIH HHS K23 AA 015313NIAAA NIH HHS K23 AA015313NIAID NIH HHS U01 AI069918NIDA NIH HHS K23 DA000523NIDA NIH HHS K23-DA 00523NIDA NIH HHS K23 DA019820NIDA NIH HHS K23-DA 019820NIDA NIH HHS K24 DA000432NIDA NIH HHS K24 DA 00432NIDA NIH HHS U01 DA036935
6 · The paper itself

Abstract

Mental illness (MI) and illicit drug use (DU) frequently co-occur. We sought to determine the individual and combined effects of MI and DU on highly active antiretroviral therapy (HAART) receipt and HIV-RNA suppression among individuals engaged in HIV care. Using 2004 data from the HIV Research Network (HIVRN), we performed a cross-sectional study of HIV-infected patients followed at seven primary care sites. Outcomes of interest were HAART receipt and virological suppression, defined as an HIV-RNA <400 copies/ml. Independent variables of interest were: (1) MI/DU; (2) DU only; (3) MI only; and (4) Neither. We used chi-squared analysis for comparison of categorical variables, and logistic regression to adjust for age, race, sex, frequency of outpatient visits, years in clinical care, CD4 nadir, and study site. During 2004, 10,284 individuals in the HIVRN were either on HAART or HAART eligible defined as a CD4 cell count < or =350. Nearly half had neither MI nor DU (41%), 22% MI only, 15% DU only, and 22% both MI and DU. In multivariate analysis, co-occurring MI/DU was associated with the lowest odds of HAART receipt (Adjusted Odds Ratio: 0.63 (95% CI: (0.55-0.72]), followed by those with DU only (0.75(0.63-0.87)), compared to those with neither. Among those on HAART, concurrent MI/DU (0.66 (0.58-0.75)), DU only (0.77 (0.67-0.88)), were also associated with a decreased odds of HIV-RNA suppression compared to those with neither. MI only was not associated with a statistically significant decrease in HAART receipt (0.93(0.81-1.07)) or viral suppression (0.93 (0.82-1.05)) compared to those with neither. Post-estimation testing revealed a significant difference between those with MI/DU and DU only, and MI/DU and MI only. Co-occurring MI and DU is associated with lower HAART receipt and viral suppression compared to individuals with either MI or DU or neither. Integrating HIV, substance abuse, and mental healthcare may improve outcomes in this population.

Indexed as

AdolescentAdultAgedAged, 80 and overAntiretroviral Therapy, Highly ActiveCD4-Positive T-LymphocytesComorbidityCross-Sectional StudiesFemaleHIV InfectionsHumansMaleMental DisordersMiddle AgedRNA, ViralSubstance-Related DisordersRNA, Viral

Identifiers

PMID19444675
PMCPMC2727701
OpenAlexW2019164256

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.