ReviewMolecular biology reports2010
The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes.
Review in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health.PloS one · 2022Pooled it
- Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability.PloS one · 2014Pooled it
- Pooled it
- Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.PLoS genetics · 2010Pooled it
- Effects of the Uncoupling Protein 1 (UCP1) A-3826G Polymorphism on Taste Preferences in Healthy Young Japanese Adults.Life (Basel, Switzerland) · 2026Article
- Serotonin Transporter Gene Polymorphisms Predict Adherence to Weight Loss Programs Independently of Obesity-Related Genes.Nutrients · 2025Article
- Genetic interaction between oxidative stress and body mass index in a Spanish population.Redox biology · 2025Article
- Evaluating a new obesity indicator for stroke risk prediction: comparative cohort analysis in rural settings of two nations.BMC public health · 2024Article
- The Role of Fucoxanthin in Non-Alcoholic Fatty Liver Disease.International journal of molecular sciences · 2023Review
- NGS Sequencing Reveals NewGenes · 2023Article
- Understanding the contemporary high obesity rate from an evolutionary genetic perspective.Hereditas · 2023Review
- Identification of Immune Infiltration and the Potential Biomarkers in Diabetic Peripheral Neuropathy through Bioinformatics and Machine Learning Methods.Biomolecules · 2022Article
- Beneficial Effects of Theaflavins on Metabolic Syndrome: From Molecular Evidence to Gut Microbiome.International journal of molecular sciences · 2022Review
- Skeletal Muscle Uncoupling Proteins in Mice Models of Obesity.Metabolites · 2022Review
- Genomic analysis to screen potential genes and mutations in children with non-syndromic early onset severe obesity: a multicentre study in Turkey.Molecular biology reports · 2022Article
- Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes.Biochemistry and biophysics reports · 2021Article
- The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue.Nature communications · 2021Article
- Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases.Molecular medicine (Cambridge, Mass.) · 2020Review
- Article
- Environmental Pollutants Effect on Brown Adipose Tissue.Frontiers in physiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uncoupling protein 1 (UCP1), a 32-kDa protein located in the inner mitochondrial membrane, is abundant in brown adipose tissue, as a proton transporter in mitochondria inner membrane which uncouples oxidative metabolism from ATP synthesis and dissipates energy through the heat. UCP1 has been reported to play important roles for energy homeostasis in rodents and neonate of larger mammals including human. Recently, numerous candidate genes were searched to determine the genetic factors implicated in the pathogenesis of obesity, related metabolic disorders and diabetes. UCP-1, which plays a major role in thermogenesis, was suggested to be one of the candidates. This review summarizes data supporting the existence of brown adipocytes and the role of UCP1 in energy dissipation in adult humans, and the genetic variety association with the fat metabolism, obesity and diabetes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.