Trial reportJournal of anesthesia2009
A randomized study of the effects of perioperative i.v. lidocaine on hemodynamic and hormonal responses for cesarean section.
Trial report in Journal of anesthesia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Lidocaine-Based vs Sufentanil-Based PCIA After Pulmonary Resection Surgery: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- Lung-Protective Effects of Lidocaine Infusion on Patients with Intermediate/ High Risk of Postoperative Pulmonary Complications: A Double-Blind Randomized Controlled Trial.Drug design, development and therapy · 2022Trial
- The Effect of Lidocaine on Postoperative Quality of Recovery and Lung Protection of Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer.Drug design, development and therapy · 2021Trial
- Anti-Inflammatory and Immunomodulatory Effects of Intravenous Lidocaine in Surgery: A Narrative Review.Journal of clinical medicine · 2025Review
- Perioperative intravenous lidocaine infusion for postsurgical pain management in bariatric surgery patients.Journal of anesthesia, analgesia and critical care · 2024Article
- Preoperative lignocaine nebulisation for attenuation of the pressor response of laryngoscopy and tracheal intubation in patients with severe preeclampsia undergoing caesarean section delivery: A randomised double-blind controlled trial.Indian journal of anaesthesia · 2023Article
- Perioperative Intravenous Lidocaine and Metastatic Cancer Recurrence - A Narrative Review.Frontiers in oncology · 2021Review
- Effect of intravenous lignocaine infusion on bispectral index during spinal anaesthesia for caesarean section: A prospective randomised double-blind study.Indian journal of anaesthesia · 2020Article
- Current Concepts in the Prevention of Perioperative Myocardial Injury.Translational perioperative and pain medicine · 2020Article
- Perioperative Use of Intravenous Lidocaine.Drugs · 2018Review
- Hemodynamic effect of intravenous lidocaine during aortic cannulation in cardiac surgery.Interventional medicine & applied science · 2017Article
- Intravenous Lidocaine versus Morphine Sulfate in Pain Management for Extremity Fractures; a Clinical Trial.Emergency (Tehran, Iran) · 2017Article
- Lidocaine Infusion: A Promising Therapeutic Approach for Chronic Pain.Journal of anesthesia & clinical research · 2017Article
- [Intravenous administration of lidocaine for perioperative analgesia. Review and recommendations for practical usage].Der Anaesthesist · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIntravenous infusion of lidocaine attenuates the stress response to surgery. We aimed to evaluate the effects of perioperative lidocaine on the hemodynamic and hormonal responses for cesarean delivery.
methodsAfter the gaining of ethical approval, 90 patients scheduled for elective cesarean delivery were randomly allocated to receive either lidocaine 1.5 mg x kg(-1) i.v. bolus 30 min before induction, followed by an infusion of 1.5 mg x kg(-1) x h(-1) until 1 h after surgery (n = 45), or saline placebo (n = 45). Anesthesia was maintained with 50% nitrous oxide in oxygen with 0.7% isoflurane. Hemodynamic variables, plasma cortisol, maternal and neonatal lidocaine concentrations, Apgar scores at 1 and 5 min, neonatal acid-base status, and the neurologic and adaptive capacity score (NACS) were recorded.
resultsAfter induction, patients receiving lidocaine had a smaller increase in heart rate and mean arterial blood pressure (P < 0.02) and lower plasma cortisol concentrations (31.1 +/- 9.91 vs 45.6 +/- 8.43 microg x dL(-1); P < 0.001). There were no differences between the two groups in Apgar scores, NACS, or neonatal acid-base status. After delivery, maternal and umbilical venous concentrations and umbilical vein-to-maternal vein ratios of lidocaine were 2.05 +/- 0.42 microg x mL(-) and 1.06 +/- 0.31 microg x mL(-1), and 0.52 +/- 0.07, respectively.
conclusionPerioperative lidocaine is safe and effective in attenuating the maternal stress response to surgery for cesarean delivery.
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