ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2009
The alpha2C-adrenoceptor deletion322-325 variant and cold-induced vasoconstriction.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- Genomic Analysis Reveals Candidate Genes Underlying Sex-Linked Eyelid Coloboma, Feather Color Traits, and Climatic Adaptation in Huoyan Geese.Animals : an open access journal from MDPI · 2023Article
- The association of an alpha2C adrenoreceptor gene polymorphism with vasomotor symptoms in African American women.Menopause (New York, N.Y.) · 2019Article
- Genetic variants in the renin-angiotensin system and blood pressure reactions to the cold pressor test.Journal of hypertension · 2010Article
- Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception.European journal of pain (London, England) · 2010Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectivesCold-induced vasoconstriction is mediated in part by selective enhancement of local alpha(2C)-adrenoceptor (alpha(2C)-AR) activity. A common insertion-deletion variant in the alpha(2C)-AR gene (ADRA2C del322-325) results in an approximately 85% reduction of agonist-mediated function in vitro. We tested the hypothesis that individuals with the ADRA2C del322-325 variant have attenuated vasoconstriction in response to cold.
methodsCutaneous digital blood flow (flux) was measured by laser Doppler flowmetry in a controlled environment at room temperature and during two cycles of graduated local heat and cold exposure in 31 subjects. Temperature-response curves were analyzed to estimate the following measures: E(min) (minimal flux during cooling), and ET(50) and ET(90) (the local temperature at which flux decreased by 50 and 90%, respectively).
resultsWe found no significant genotypic differences in E(min) (24.3 +/- 19.5, 30.0 +/- 20.5, and 21.5 +/- 25.9 AU for ins/ins, ins/del, and del/del genotypes, respectively; P = 0.48), ET(50) (25.5 +/- 6.0, 25.1 +/- 6.7, and 25.1 +/- 7.1 degrees C; P = 0.99), or ET(90) (20.5 +/- 4.7, 22.1 +/- 4.0, and 20.8 +/- 6.7 degrees C; P = 0.77) in either the first or second heating and cooling cycle (cycle 1 values presented).
interpretationThe ADRA2C del322-325 variant did not affect vascular sensitivity to local cold exposure.
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