ArticleJournal of neurology2009
Recent advances in the diagnosis, genetics and treatment of restless legs syndrome.
Article in Journal of neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Efficacy and safety of pharmacological treatments for restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- RLS shows increased resting state sympathetic activity and decreased sympathetic response capability.Journal of neurology · 2025Article
- No association between obstructive sleep apnea and restless legs syndrome: results from a large hospital-based cross-sectional study.Frontiers in sleep · 2025Article
- Stroke-related restless leg syndrome in hemorrhagic and ischemic stroke patients.SAGE open medicine · 2025Article
- Association between Self-Perceived Periodic Limb Movement during Sleep and Excessive Daytime Sleepiness Depend on Restless Leg Symptoms in Korean Adolescents.International journal of environmental research and public health · 2022Article
- Autonomic dysfunction in restless legs syndrome.Sleep & breathing = Schlaf & Atmung · 2020Article
- [Genetic risk variants in Parkinson's disease and other movement disorders].Der Nervenarzt · 2017Review
- Brain imaging and networks in restless legs syndrome.Sleep medicine · 2017Review
- Restless legs syndrome as a first manifestation of a cerebral infarct.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2014Article
- Article
- Association between sleep disorders, obesity, and exercise: a review.Nature and science of sleep · 2013Article
- Sleep-related movement disorders.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2012Review
- Recurrent CSPs after Transcranial Magnetic Stimulation of Motor Cortex in Restless Legs Syndrome.Neurology research international · 2012Article
- The Effects of a Gentle Yoga Program on Sleep, Mood, and Blood Pressure in Older Women with Restless Legs Syndrome (RLS): A Preliminary Randomized Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Restless legs syndrome and hypertension in middle-aged women.Hypertension (Dallas, Tex. : 1979) · 2011Article
- Genetics of sleep and sleep disorders.Cell · 2011Review
- Review
- Iron deficiency: beyond anemia.Indian journal of pediatrics · 2011Review
- Restless legs syndrome: pathophysiology, clinical presentation and management.Nature reviews. Neurology · 2010Review
- Ropinirole in restless legs syndrome and periodic limb movement disorder.Therapeutics and clinical risk management · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowledge of restless legs syndrome (RLS) has greatly increased in recent years due to the many advances that have been made in diagnosis, management and genetics. Tools have been developed that facilitate the diagnosis and treatment of RLS, in particular the essential diagnostic criteria for RLS have been refined, severity scales (IRLS, RLS-6, JHSS) have been developed, as have instruments that improve diagnostic accuracy and assess for specific aspects of RLS such as augmentation. These newly developed tools have been used in recent population-based studies, which have provided a greater understanding of the epidemiology of RLS, and also within patient-based trials. As far as the genetics of RLS is concerned, linkage studies in RLS families have revealed eight loci but no causally related sequence variant has yet been identified using this approach. Recent genome-wide association studies have identified variants within intronic or intergenic regions of MEIS1, BTBD9, and MAP2K5/LBXCOR1, and PTPRD, raising new pathological hypotheses for RLS. An overview on therapeutic options and recent trials is given based on evidence-based management strategies for this common disorder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.