Evidence map›Paper›PMID 19444507›Full record

ReviewMammalian genome : official journal of the International Mammalian Genome Society2009

Murine models of colorectal cancer.

Joshua M Uronis, David W Threadgill

Abstract readReview
In one paragraph

Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. More than two decades of Apc modeling in rodents.Biochimica et biophysica acta · 2013
    Review
  7. Transformation of epithelial cells through recruitment leads to polyclonal intestinal tumors.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  8. Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The armadillo repeat domain of Apc suppresses intestinal tumorigenesis.Mammalian genome : official journal of the International Mammalian Genome Society · 2010
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joshua M UronisCurriculum in Genetics and Molecular Biology, Department of Genetics, Lineberger Cancer Center and Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC 27599, USA.
David W Threadgill
UNC Lineberger Comprehensive Cancer Center

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
TISSUE PROCUREMENT &ANALYSISP50CA106991 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TEPPER, JOEL E · 2004 to 2009
$12.1M
Modeling heterogeneity for safe cancer prevention and detectionU01CA105417 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THREADGILL, DAVID W. · 2004 to 2013
$6.7M
ERBB receptors in normal and cancerous colon biologyR01CA092479 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THREADGILL, DAVID W. · 2001 to 2012
$2.8M
Genetic control of colorectal cancer histopathologyR01CA079869 · NCI · VANDERBILT UNIVERSITY · PI THREADGILL, DAVID W. · 1999 to 2013
$2.7M
NCI NIH HHS P30 CA016086NCI NIH HHS P30CA016086NCI NIH HHS P50 CA106991NCI NIH HHS P50CA106991NCI NIH HHS R01 CA079869NCI NIH HHS R01 CA092479NCI NIH HHS R01CA092479NCI NIH HHS U01 CA105417NCI NIH HHS U01CA105417NIDDK NIH HHS P30 DK034987NIDDK NIH HHS P30DK34987
6 · The paper itself

Abstract

Colorectal cancer is one of the most prevalent cancers of humans. To experimentally investigate this common disease, numerous murine models have been established. These models accurately recapitulate the molecular and pathologic characteristics of human colorectal cancers, including activation of the myelocytomatosis oncogene (MYC), which has recently been suggested to be a key mediator of colorectal cancer development. This review focuses on the variety of murine models of human colorectal cancer that are available to the research community and on their use to identify common and distinct characteristics of colorectal cancer.

Indexed as

Disease Models, AnimalMiceAnimalsColorectal NeoplasmsHumansMice, Inbred StrainsProto-Oncogene Proteins c-mycSignal TransductionProto-Oncogene Proteins c-myc

Identifiers

PMID19444507
PMCPMC2819073
OpenAlexW2062079324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.