ArticlePediatric nephrology (Berlin, Germany)2009
Urinary tract infections: to prophylaxis or not to prophylaxis?
Article in Pediatric nephrology (Berlin, Germany), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Evidence for and against urinary prophylaxis in vesicoureteral reflux.Pediatric nephrology (Berlin, Germany) · 2010Pooled it
- Review
- Review
- Congenital anomalies of the kidney and urinary tract: antenatal diagnosis, management and counselling of families.Pediatric nephrology (Berlin, Germany) · 2024Article
- Vesico-ureteric reflux in children and young people undergoing kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2023Article
- Retrospective 8-Year Study on the Antibiotic Resistance of Uropathogens in Children Hospitalised for Urinary Tract Infection in the Emilia-Romagna Region, Italy.Antibiotics (Basel, Switzerland) · 2021Article
- Vesicoureteral reflux is it important to find?Pediatric nephrology (Berlin, Germany) · 2021Review
- Primary vesicoureteral reflux; what have we learnt from the recently published randomized, controlled trials?Pediatric nephrology (Berlin, Germany) · 2019Review
- Susceptibility of the Index Urinary Tract Infection to Prophylactic Antibiotics Is a Predictive Factor of Breakthrough Urinary Tract Infection in Children with Primary Vesicoureteral Reflux Receiving Continuous Antibiotic Prophylaxis.Journal of Korean medical science · 2019Article
- Antimicrobial misuse in pediatric urinary tract infections: recurrences and renal scarring.Annals of clinical microbiology and antimicrobials · 2018Article
- The RIVUR trial: a factual interpretation of our data.Pediatric nephrology (Berlin, Germany) · 2015Article
- Practical approach to screen vesicoureteral reflux after a first urinary tract infection.Indian journal of urology : IJU : journal of the Urological Society of India · 2014Article
- Long-term resistance trends of uropathogens and association with antimicrobial prophylaxis.Pediatric nephrology (Berlin, Germany) · 2014Article
- Does hydronephrosis predict the presence of severe vesicoureteral reflux?European journal of pediatrics · 2012Article
- Prevention of chronic kidney disease in spina bifida.International urology and nephrology · 2012Review
- Screening high-grade vesicoureteral reflux in young infants with a febrile urinary tract infection.Pediatric nephrology (Berlin, Germany) · 2012Article
- Changes in bacterial resistance patterns in children with urinary tract infections on antimicrobial prophylaxis at University Hospital in Split.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
- Pediatric urinary tract infections: an analysis of hospitalizations, charges, and costs in the USA.Pediatric nephrology (Berlin, Germany) · 2010Article
- Evaluating different imaging strategies in children after first febrile urinary tract infection.Pediatric nephrology (Berlin, Germany) · 2010Article
- Outcome and management of isolated severe renal pelvis dilatation detected at postnatal screening.Pediatric nephrology (Berlin, Germany) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary tract infections, with or without reflux, are the most frequent reason for long-term antibacterial prophylaxis in infants and children. When one is considering the use of prophylaxis in these children, what is clear from existing published data? Up to 2006 there were a small number of poor quality studies, with no reliable evidence of the effectiveness of antibiotics in preventing recurrent symptomatic urinary tract infections (UTIs). Since then, four randomised controlled studies, to assess the benefits, or lack thereof, of antibiotic prophylaxis, have been published. None has demonstrated a clear benefit. The following conclusions can be drawn: antibiotic prophylaxis is not indicated for children following a first febrile UTI if no or mild grade I or II reflux is present; for higher grade reflux there is no definite conclusion.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.