ArticleInternational urogynecology journal and pelvic floor dysfunction2009
COL3A1 2209G>A is a predictor of pelvic organ prolapse.
Article in International urogynecology journal and pelvic floor dysfunction, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Pooled it
- Association between joint hypermobility and pelvic organ prolapse in women: a systematic review and meta-analysis.International urogynecology journal · 2016Pooled it
- Genetic epidemiology of pelvic organ prolapse: a systematic review.American journal of obstetrics and gynecology · 2014Pooled it
- A systematic review of clinical studies on hereditary factors in pelvic organ prolapse.International urogynecology journal · 2012Pooled it
- Verification of the Chromosome Region 9q21 Association with Pelvic Organ Prolapse Using RegulomeDB Annotations.BioMed research international · 2015Trial
- Review
- Genetics of Female Pelvic Organ Prolapse: Up to Date.Biomolecules · 2024Review
- Perioperative outcomes following pelvic floor reconstruction in women with hereditary disorders of connective tissue: a retrospective cohort study.International urogynecology journal · 2021Article
- Collagen type 3A1 and 1A1 polymorphisms in women with pelvic organ prolapse and urinary incontinence assessed with Sanger sequencing method.Central European journal of urology · 2021Article
- Genetic polymorphisms in collagen-related genes are associated with pelvic organ prolapse.Menopause (New York, N.Y.) · 2020Article
- Identification of pelvic organ prolapse risk susceptibility gene SNP locus in Xinjiang women.International urogynecology journal · 2020Article
- Polymorphism rs1800255 from COL3A1 gene and the risk for pelvic organ prolapse.International urogynecology journal · 2020Article
- Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.Nature communications · 2017Article
- Article
- The genetic epidemiology of diverticulosis and diverticular disease: Emerging evidence.United European gastroenterology journal · 2015Review
- Overrepresentation of the COL3A1 AA genotype in Polish skiers with anterior cruciate ligament injury.Biology of sport · 2015Article
- Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative.PloS one · 2015Article
- Collagen type III alpha 1 polymorphism (rs1800255, COL3A1 2209 G>A) assessed with high-resolution melting analysis is not associated with pelvic organ prolapse in the Dutch population.International urogynecology journal · 2014Article
- Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse.American journal of obstetrics and gynecology · 2012Article
- Pelvic organ prolapse and collagen-associated disorders.International urogynecology journal · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisA familial tendency has been demonstrated in the etiology of pelvic organ prolapse (POP), but the specific genetic defects have not been identified. Type III collagen is an important factor in the repair of connective tissue, and gene polymorphisms may impair the tensile strength. We hypothesized that polymorphisms in the alpha I chain of the type III collagen protein-encoding gene (COL3A1) pose women at risk for POP.
methodsIn this case-control study, the prevalence of type III collagen polymorphisms was compared in women with and without signs and symptoms of POP.
resultsTwo hundred and two POP patients and 102 normal parous controls were included. A homozygous single-nucleotide substitution in the coding region of type III collagen (COL3A1 2209G>A, rs1800255) was identified in 27 (13%) POP patients and three (3%) controls (odds ratio, 5.0; 95% confidence interval, 1.4-17.1).
conclusionsThe probability of POP was higher in women with COL3A1 2209G>A. This polymorphism showed to be a relevant risk factor for POP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.