ArticleThe open dentistry journal2008
Mast cells and angiogenesis in oral malignant and premalignant lesions.
Article in The open dentistry journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review.Molecular cancer · 2019Pooled it
- Chorus line in oral squamous cell carcinoma: How stromal and immune players orchestrate tumor progression (Review).International journal of molecular medicine · 2026Review
- Assessment of Expression of Mast Cells Density in Oral Premalignant and Malignant Lesions by Histochemical Analysis.Journal of pharmacy & bioallied sciences · 2024Article
- Comparison of Mast Cell Count in Oral Epithelial Dysplasia and Squamous Cell Carcinoma.Journal of dentistry (Shiraz, Iran) · 2024Article
- Review
- Precancerous Lesions of the Head and Neck Region and Their Stromal Aberrations: Piecemeal Data.Cancers · 2023Review
- Is CCL2 an Important Mediator of Mast Cell-Tumor Cell Interactions in Oral Squamous Cell Carcinoma?International journal of molecular sciences · 2023Article
- Article
- Correlation of Mast Cell and Angiogenesis in Oral Lichen Planus, Dysplasia (Leukoplakia), and Oral Squamous Cell Carcinoma.Rambam Maimonides medical journal · 2021Article
- Evaluation of Mast Cells in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma.International journal of dentistry · 2021Article
- Evaluation of Mast Cell Density using CD117 antibody and Microvessel Density Using CD34 Antibody in Different Grades of Oral Squamous Cell Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Article
- Histomorphometric comparative analysis between the oral mucosa of fibrous inflammatory hyperplasia and oral leukoplakia.Translational cancer research · 2020Article
- Mast Cells and Blood Vessels Profile in Oral Carcinogenesis: An Immunohistochemistry Study.Asian Pacific journal of cancer prevention : APJCP · 2020Observational
- Histomorphometric Comparative Analysis between Oral Dysplastic Potentially Malignant Disorders and Oral Squamous Cell Carcinoma.European journal of dentistry · 2019Article
- Serum and salivary levels of chemerin and MMP-9 in oral squamous cell carcinoma and oral premalignant lesions.Clinical oral investigations · 2017Article
- Correlation of Vascularization and Inflammation with Severity of Oral Leukoplakia.Iranian journal of pathology · 2017Article
- The role of mast cells in oral squamous cell carcinoma.Contemporary oncology (Poznan, Poland) · 2017Review
- Immunohistochemical Evaluation of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma.Journal of clinical and diagnostic research : JCDR · 2016Article
- Incidence of Mast Cells in Gingival and Periapical Inflammation- A Kaleidoscopic Study.Journal of clinical and diagnostic research : JCDR · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledMast cell contribution to neoangiogenesis during tumorigenesis in oral squamous cell carcinoma is not determined yet.
objectivesTo associate numerical mast cell density (MCD) to numerical microvessel density (MVD) during the progression of oral leukoplakia without dysplasia and leukoplakia with dysplasia to squamous cell carcinoma (OSCC). MATERIALS AND
methodsMVD was analysed immunohistochemically (mouse monoclonal anti-human CD34) in 49 paraffin-embedded specimens, 35 OSCCs, 9 leukoplakias and 5 normal oral tissues. Toluidine blue counterstaining revealed mast cells. MCD and MVD were assessed at the same optical field.
resultsMVD increased between: normal oral mucosa, dysplasia (p=0.004), OSCC (p=0.001), leukoplakia and OSCC (p=0.041). MCD increased between: normal oral mucosa, dysplasia (p=0.003), OSCC (p=0.000), leukoplakia and OSCC (p=0.007). MVD was found to depend on MCD (p=0.000) in a percent 28.3% (power curve fit model).
conclusionsMast cells are attracted at the lesion site and may turn on an angiogenic switch during tumorigenesis in OSCC.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.