Evidence map›Paper›PMID 19444269›Full record

ArticleKidney international2009

Ablation of klotho and premature aging: is 1,25-dihydroxyvitamin D the key middleman?

Yuen Fei Wong, Qihe Xu

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Kidney international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. The virtues of vitamin D--but how much is too much?Pediatric nephrology (Berlin, Germany) · 2010
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yuen Fei WongKing's College London, Department of Renal Medicine, Rayne Institute, London, UK.
Qihe XuKing's College London, Department of Renal Medicine, Rayne Institute, London, UK. Electronic address: qihe.xu@kcl.ac.uk.
King's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The reversal of soft-tissue abnormalities and prolonged lifespan observed in klotho(-/-) mice following genetic inactivation of 1alpha-hydroxylase underscores the pathophysiological role of 1,25-dihydroxyvitamin D in mediating some of the premature aging-like features observed in klotho(-/-) mice.

Indexed as

Gene Silencing25-Hydroxyvitamin D3 1-alpha-HydroxylaseAging, PrematureAnimalsGlucuronidaseKlotho ProteinsLongevityMiceMice, KnockoutVitamin D1,25-dihydroxyvitamin D25-Hydroxyvitamin D3 1-alpha-HydroxylaseGlucuronidaseKlotho ProteinsVitamin D

Identifiers

PMID19444269
OpenAlexW2079333891

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.